Anti-C6 Antibody (CAB10170)
- SKU:
- CAB10170
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-C6 Antibody |
| 抗体コード: | CAB10170 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-260 of human C6 (NP_000056.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse liver, Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-260 of human C6 (NP_000056.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | CFCD HYAW TQWT SCSK TCNS GTQS RHRQ IVVD KYYQ ENFC EQIC SKQE TREC NWQR CPIN CLLG DFGP WSDC DPCI EKQS KVRS VLRP SQFG GQPC TAPL VAFQ PCIP SKLC KIEE ADCK NKFR CDSG RCIA RKLE CNGE NDCG DNSD ERDC GRTK AVCT RKYN PIPS VQLM GNGF HFLA GEPR GEVL DNSF TGGI CKTV KSSR TSNP YRVP ANLE NVGF EVQT AEDD LKTD FYKD LTS |
| 遺伝子ID: | 729 |
| Uniprot: | P13671 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 104kDa |
| 観察された分子量: | 110kDa |
| 同義語: | C6 |
| バックグラウンド: | This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described. |
| UniProt Protein Function: | C6: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C6 are the cause of complement component 6 deficiency (C6D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5p13.1 Cellular Component: extracellular region; membrane attack complex Molecular Function:protein binding Biological Process: complement activation; regulation of complement activation Disease: Complement Component 6 Deficiency |
| NCBI Summary: | This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012] |
| UniProt Code: | P13671 |
| NCBI GenInfo Identifier: | 146345396 |
| NCBI Gene ID: | 729 |
| NCBI Accession: | P13671.3 |
| UniProt Related Accession: | P13671 |
| Molecular Weight: | 104,786 Da |
| NCBI Full Name: | Complement component C6 |
| NCBI Synonym Full Names: | complement C6 |
| NCBI Official Symbol: | C6 |
| NCBI Protein Information: | complement component C6 |
| UniProt Protein Name: | Complement component C6 |
| Protein Family: | Complement component |
| UniProt Gene Name: | C6 |
 | Western blot analysis of extracts of various cell lines, using C6 antibody (CAB10170) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |