Anti-C1GALT1 Antibody (CAB12865)
- SKU:
- CAB12865
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-C1GALT1 Antibody |
| 抗体コード: | CAB12865 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 194-363 of human C1GALT1 (NP_064541.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 194-363 of human C1GALT1 (NP_064541.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | FGRR FKPY VKQG YMSG GAGY VLSK EALK RFVD AFKT DKCT HSSS IEDL ALGR CMEI MNVE AGDS RDTI GKET FHPF VPEH HLIK GYLP RTFW YWNY NYYP PVEG PGCC SDLA VSFH YVDS TTMY ELEY LVYH LRPY GYLY RYQP TLPE RILK EISQ ANKN EDTK VKLG NP |
| 遺伝子ID: | 56913 |
| Uniprot: | Q9NS00 |
| セルラーロケーション: | Membrane, Single-pass type II membrane protein |
| 計算された分子量: | 35kDa/42kDa |
| 観察された分子量: | 42kDa |
| 同義語: | C1GALT1, C1GALT, T-synthase |
| バックグラウンド: | The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis. |
| UniProt Protein Function: | C1GALT1: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development. Belongs to the glycosyltransferase 31 family. Beta3- Gal-T subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.4.1.122; Glycan Metabolism - O-glycan biosynthesis; Transferase; Membrane protein, integral Chromosomal Location of Human Ortholog: 7p21.3 Cellular Component: Golgi membrane; integral to membrane Molecular Function:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; protein binding Biological Process: angiogenesis; kidney development; O-glycan processing; O-glycan processing, core 1 |
| NCBI Summary: | The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.[provided by RefSeq, Sep 2010] |
| UniProt Code: | Q9NS00 |
| NCBI GenInfo Identifier: | 74719147 |
| NCBI Gene ID: | 56913 |
| NCBI Accession: | Q9NS00.1 |
| UniProt Secondary Accession: | Q9NS00,Q96QH4, Q9BTU1, |
| UniProt Related Accession: | Q9NS00 |
| Molecular Weight: | 35,935 Da |
| NCBI Full Name: | Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 |
| NCBI Synonym Full Names: | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 |
| NCBI Official Symbol: | C1GALT1 |
| NCBI Official Synonym Symbols: | C1GALT; T-synthase |
| NCBI Protein Information: | glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 |
| UniProt Protein Name: | Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 |
| UniProt Synonym Protein Names: | B3Gal-T8; Core 1 O-glycan T-synthase; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; Beta-1,3-galactosyltransferase; Core 1 beta1,3-galactosyltransferase 1; C1GalT1; Core 1 beta3-Gal-T1 |
| Protein Family: | C1GALT1-specific chaperone |
| UniProt Gene Name: | C1GALT1 |
| UniProt Entry Name: | C1GLT_HUMAN |
 | Western blot analysis of extracts of mouse kidney, using C1GALT1 antibody (CAB12865) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human lung using C1GALT1 antibody (CAB12865) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using C1GALT1 antibody (CAB12865) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using C1GALT1 antibody (CAB12865) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using C1GALT1 antibody (CAB12865) at dilution of 1:100 (40x lens). |
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