Anti-C1 Inactivator Antibody (CAB1717)
- SKU:
- CAB1717
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-C1 Inactivator Antibody |
| 抗体コード: | CAB1717 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 201-500 of human C1 Inactivator (NP_001027466.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:1000 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | DU145, SKOV3, HeLa, LO2, U-251MG, Mouse liver, Mouse lung, Rat heart, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 201-500 of human C1 Inactivator (NP_001027466.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KDFT CVHQ ALKG FTTK GVTS VSQI FHSP DLAI RDTF VNAS RTLY SSSP RVLS NNSD ANLE LINT WVAK NTNN KISR LLDS LPSD TRLV LLNA IYLS AKWK TTFD PKKT RMEP FHFK NSVI KVPM MNSK KYPV AHFI DQTL KAKV GQLQ LSHN LSLV ILVP QNLK HRLE DMEQ ALSP SVFK AIME KLEM SKFQ PTLL TLPR IKVT TSQD MLSI MEKL EFFD FSYD LNLC GLTE DPDL QVSA MQHQ TVLE LTET GVEA AAAS AISV ARTL LVFE VQQP FLFV LWDQ QHKF PVFM GRVY DPRA |
| 遺伝子ID: | 710 |
| Uniprot: | P05155 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 49kDa/55kDa |
| 観察された分子量: | 60kDa.110kDa |
| 同義語: | SERPING1, C1IN, C1INH, C1NH, HAE1, HAE2 |
| バックグラウンド: | This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. |
| UniProt Protein Function: | SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11q12.1 Cellular Component: extracellular space; extracellular region Molecular Function:serine-type endopeptidase inhibitor activity; protein binding Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; complement activation, classical pathway; blood coagulation, intrinsic pathway; aging Disease: Complement Component 4, Partial Deficiency Of; Angioedema, Hereditary, Type I |
| NCBI Summary: | This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05155 |
| NCBI GenInfo Identifier: | 124096 |
| NCBI Gene ID: | 710 |
| NCBI Accession: | P05155.2 |
| UniProt Secondary Accession: | P05155,Q16304, Q547W3, Q59EI5, Q7Z455, Q96FE0, Q9UC49 A6NMU0, A8KAI9, B2R6L5, B4E1F0, B4E1H2, |
| UniProt Related Accession: | P05155 |
| Molecular Weight: | |
| NCBI Full Name: | Plasma protease C1 inhibitor |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 |
| NCBI Official Symbol: | SERPING1 |
| NCBI Official Synonym Symbols: | C1IN; C1NH; HAE1; HAE2; C1INH |
| NCBI Protein Information: | plasma protease C1 inhibitor; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1 |
| UniProt Protein Name: | Plasma protease C1 inhibitor |
| UniProt Synonym Protein Names: | C1 esterase inhibitor; C1-inhibiting factor; Serpin G1 |
| Protein Family: | Para-Rep |
| UniProt Gene Name: | SERPING1 |
| UniProt Entry Name: | IC1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using C1 Inactivator antibody (CAB1717) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
 | Immunofluorescence analysis of C6 cells using C1 Inactivator antibody ( A1717) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of HeLa cells using C1 Inactivator antibody ( A1717) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of NIH/3T3 cells using C1 Inactivator antibody ( A1717) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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