| UniProt Protein Function: | BRSK1: a serine/threonine protein kinase of the CAMK group. Closely related to AMPK. Activated by the kinase LKB1. Acts as checkpoint kinase upon DNA damage induced by UV or methyl methane sulfonate. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo. Translocates from the cytoplasm to the nucleus in response to UV- or MMS-induced DNA damage. BRSK1 and BRSK2 are required for neuronal polarization. Widely expressed with highest levels in the brain and testis. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.26; EC 2.7.11.1; CAMK group; CAMKL family; BRSK subfamily Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: nucleoplasm; centrosome; synaptic vesicle; cytoplasm; cell junction; nucleus Molecular Function:protein serine/threonine kinase activity; gamma-tubulin binding; tau-protein kinase activity; magnesium ion binding; protein kinase binding; ATP binding Biological Process: neuron differentiation; axonogenesis; establishment of cell polarity; neurotransmitter secretion; response to ionizing radiation; G2/M transition DNA damage checkpoint; centrosome duplication; response to DNA damage stimulus; protein amino acid phosphorylation; response to UV |
| UniProt Code: | Q8TDC3 |
| NCBI GenInfo Identifier: | 34395684 |
| NCBI Gene ID: | 84446 |
| NCBI Accession: | Q8TDC3.1 |
| UniProt Secondary Accession: | Q8TDC3,Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4 F1DG44, |
| UniProt Related Accession: | Q8TDC3 |
| Molecular Weight: | 38,782 Da |
| NCBI Full Name: | BR serine/threonine-protein kinase 1 |
| NCBI Synonym Full Names: | BR serine/threonine kinase 1 |
| NCBI Official Symbol: | BRSK1 |
| NCBI Official Synonym Symbols: | hSAD1 |
| NCBI Protein Information: | serine/threonine-protein kinase BRSK1; SAD1 kinase; SAD1 homolog; protein kinase SAD1A; brain-selective kinase 1; SadB kinase short isoform; BR serine/threonine-protein kinase 1; serine/threonine-protein kinase SAD-B; synapses of Amphids Defective homolog 1; brain-specific serine/threonine-protein kinase 1 |
| UniProt Protein Name: | Serine/threonine-protein kinase BRSK1 |
| UniProt Synonym Protein Names: | Brain-selective kinase 1 (EC:2.7.11.26); Brain-specific serine/threonine-protein kinase 1; BR serine/threonine-protein kinase 1; Serine/threonine-protein kinase SAD-B; Synapses of Amphids Defective homolog 1; SAD1 homolog; hSAD1 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | BRSK1 |
| UniProt Entry Name: | BRSK1_HUMAN |
