Anti-BRD2 Antibody (CAB16241)
- SKU:
- CAB16241
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-BRD2 Antibody |
| 抗体コード: | CAB16241 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BRD2 (NP_001186385.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse brian |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BRD2 (NP_001186385.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MASV PALQ LTPA NPPP PEVS NPKK PGRV TNQL QYLH KVVM KALW KHQF AWPF RQPV DAVK LGLP DYHK IIKQ PMDM GTIK RRLE NNYY WAAS ECMQ DFNT |
| 遺伝子ID: | 6046 |
| Uniprot: | P25440 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 74kDa/83kDa/88kDa/92kDa |
| 観察された分子量: | 110kDa |
| 同義語: | BRD2, BRD2-IT1, D6S113E, FSH, FSRG1, NAT, O27.1.1, RING3, RNF3 |
| バックグラウンド: | This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. |
| UniProt Protein Function: | May play a role in spermatogenesis or folliculogenesis. Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. |
| NCBI Summary: | This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | P25440 |
| NCBI GenInfo Identifier: | 12230989 |
| NCBI Gene ID: | 6046 |
| NCBI Accession: | P25440.2 |
| UniProt Secondary Accession: | P25440,O00699, O00700, Q15310, Q5STC9, Q63HQ9, Q658Y7 Q6P3U2, Q969U4, A2AAU0, B0S7P0, B1AZT1, |
| UniProt Related Accession: | P25440 |
| Molecular Weight: | 74,881 Da |
| NCBI Full Name: | Bromodomain-containing protein 2 |
| NCBI Synonym Full Names: | bromodomain containing 2 |
| NCBI Official Symbol: | BRD2 |
| NCBI Official Synonym Symbols: | FSH; NAT; RNF3; FSRG1; RING3; D6S113E; O27.1.1 |
| NCBI Protein Information: | bromodomain-containing protein 2 |
| UniProt Protein Name: | Bromodomain-containing protein 2 |
| UniProt Synonym Protein Names: | O27.1.1; Really interesting new gene 3 protein |
| Protein Family: | Bromodomain-containing protein |
| UniProt Gene Name: | BRD2 |
| UniProt Entry Name: | BRD2_HUMAN |
 | Western blot analysis of extracts of mouse brian, using BRD2 antibody (CAB16241) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |