Anti-BMPR1B Antibody (CAB2005)
- SKU:
- CAB2005
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-BMPR1B Antibody |
| 抗体コード: | CAB2005 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-126 of human BMPR1B (NP_001194.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, HeLa, SH-SY5Y |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-126 of human BMPR1B (NP_001194.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MLLR SAGK LNVG TKKE DGES TAPT PRPK VLRC KCHH HCPE DSVN NICS TDGY CFTM IEED DSGL PVVT SGCL GLEG SDFQ CRDT PIPH QRRS IECC TERN ECNK DLHP TLPP LKNR DFVD GPIH HR |
| 遺伝子ID: | 658 |
| Uniprot: | O00238 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 56kDa/60kDa |
| 観察された分子量: | 51KDa |
| 同義語: | ALK-6, ALK6, AMDD, BDA1D, BDA2, CDw293, BMPR1B |
| バックグラウンド: | This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. |
| UniProt Protein Function: | BMPR1B: a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor. |
| UniProt Protein Details: | Protein type:Protein kinase, TKL; EC 2.7.11.30; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Kinase, protein; TKL group; STKR family; Type1 subfamily Chromosomal Location of Human Ortholog: 4q22-q24 Cellular Component: integral to plasma membrane; plasma membrane; receptor complex Molecular Function:protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; metal ion binding; SMAD binding; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity Biological Process: chondrocyte development; positive regulation of bone mineralization; limb morphogenesis; protein amino acid phosphorylation; BMP signaling pathway; positive regulation of osteoblast differentiation; ovulation cycle; eye development; dorsal/ventral pattern formation; retina development in camera-type eye; proteoglycan biosynthetic process; ovarian cumulus expansion; positive regulation of cell differentiation; inflammatory response; skeletal development; retinal ganglion cell axon guidance; cartilage condensation Disease: Chondrodysplasia, Acromesomelic, With Genital Anomalies; Brachydactyly, Type A2 |
| NCBI Summary: | This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | O00238 |
| NCBI GenInfo Identifier: | 6226778 |
| NCBI Gene ID: | 658 |
| NCBI Accession: | O00238.1 |
| UniProt Secondary Accession: | O00238,P78366, B2R953, B4DSV1, |
| UniProt Related Accession: | O00238 |
| Molecular Weight: | 502 |
| NCBI Full Name: | Bone morphogenetic protein receptor type-1B |
| NCBI Synonym Full Names: | bone morphogenetic protein receptor, type IB |
| NCBI Official Symbol: | BMPR1B |
| NCBI Official Synonym Symbols: | ALK6; ALK-6; CDw293 |
| NCBI Protein Information: | bone morphogenetic protein receptor type-1B; BMPR-1B; BMP type-1B receptor; activin receptor-like kinase 6; serine/threonine receptor kinase |
| UniProt Protein Name: | Bone morphogenetic protein receptor type-1B |
| UniProt Synonym Protein Names: | CD_antigen: CDw293 |
| Protein Family: | Bone morphogenetic protein receptor |
| UniProt Gene Name: | BMPR1B |
| UniProt Entry Name: | BMR1B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BMPR1B Rabbit pAb (CAB2005) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using BMPR1B antibody (CAB2005) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat ovary using BMPR1B antibody (CAB2005) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse liver using BMPR1B antibody (CAB2005) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of L929 cells using BMPR1B antibody (CAB2005) at dilution of 1:100. Blue: DAPI for nuclear staining. |