Anti-BMP6 Antibody (CAB8333)
- SKU:
- CAB8333
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-BMP6 Antibody |
| 抗体コード: | CAB8333 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human BMP6 (NP_001709.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | DU145, Mouse lung, Mouse kidney, Mouse heart, Rat brain, Rat kidney |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human BMP6 (NP_001709.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QQPQ PPAL RQQE EQQQ QQQL PRGE PPPG RLKS APLF MLDL YNAL SADN DEDG ASEG ERQQ SWPH EAAS SSQR RQPP PGAA HPLN RKSL LAPG SGSG GASP L |
| 遺伝子ID: | 654 |
| Uniprot: | P22004 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 57kDa |
| 観察された分子量: | 57kDa |
| 同義語: | BMP6, VGR, VGR1 |
| バックグラウンド: | The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. |
| UniProt Protein Function: | Induces cartilage and bone formation. |
| NCBI Summary: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016] |
| UniProt Code: | P22004 |
| NCBI GenInfo Identifier: | 115076 |
| NCBI Gene ID: | 654 |
| NCBI Accession: | P22004.1 |
| UniProt Secondary Accession: | P22004,Q5TCP3, |
| UniProt Related Accession: | P22004 |
| Molecular Weight: | 57,226 Da |
| NCBI Full Name: | Bone morphogenetic protein 6 |
| NCBI Synonym Full Names: | bone morphogenetic protein 6 |
| NCBI Official Symbol: | BMP6 |
| NCBI Official Synonym Symbols: | VGR; VGR1 |
| NCBI Protein Information: | bone morphogenetic protein 6 |
| UniProt Protein Name: | Bone morphogenetic protein 6 |
| UniProt Synonym Protein Names: | VG-1-related protein; VG-1-R; VGR-1 |
| Protein Family: | Bone morphogenetic protein |
| UniProt Gene Name: | BMP6 |
 | Western blot analysis of extracts of various cell lines, using BMP6 Antibody (CAB8333) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of HeLa cells using BMP6 antibody (CAB8333) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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