Anti-BMP15 Antibody (CAB4148)
- SKU:
- CAB4148
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-BMP15 Antibody |
| 抗体コード: | CAB4148 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human BMP15 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SKOV3, A-431, Mouse lung, Mouse ovary, Mouse kidney, Rat ovary |
| 免疫原: | A synthesized peptide derived from human BMP15 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 9210 |
| Uniprot: | O95972 |
| セルラーロケーション: | |
| 計算された分子量: | 50kDa |
| 観察された分子量: | 50KDa |
| 同義語: | GDF9B, ODG2, POF4 |
| バックグラウンド: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016] |
| UniProt Protein Function: | BMP15: May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2); also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea. Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4). An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cytokine Chromosomal Location of Human Ortholog: Xp11.2 Cellular Component: extracellular space; cytoplasm Molecular Function:growth factor activity; cytokine activity; transforming growth factor beta receptor binding Biological Process: BMP signaling pathway; regulation of apoptosis; granulosa cell development; ovarian follicle development; positive regulation of transcription, DNA-dependent; regulation of MAPKKK cascade; female gamete generation; cell development Disease: Ovarian Dysgenesis 2 |
| NCBI Summary: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016] |
| UniProt Code: | O95972 |
| NCBI GenInfo Identifier: | 51338749 |
| NCBI Gene ID: | 9210 |
| NCBI Accession: | O95972.2 |
| UniProt Related Accession: | O95972 |
| Molecular Weight: | |
| NCBI Full Name: | Bone morphogenetic protein 15 |
| NCBI Synonym Full Names: | bone morphogenetic protein 15 |
| NCBI Official Symbol: | BMP15 |
| NCBI Official Synonym Symbols: | ODG2; POF4; GDF9B |
| NCBI Protein Information: | bone morphogenetic protein 15 |
| UniProt Protein Name: | Bone morphogenetic protein 15 |
| UniProt Synonym Protein Names: | Growth/differentiation factor 9B |
| Protein Family: | Bone morphogenetic protein |
| UniProt Gene Name: | BMP15 |
| UniProt Entry Name: | BMP15_HUMAN |
 | Western blot - BMP15 Rabbit mAb (CAB4148) |
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