Anti-BMP10 Antibody (CAB15010)
- SKU:
- CAB15010
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-BMP10 Antibody |
| 抗体コード: | CAB15010 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-316 of human BMP10 (NP_055297.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: | rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-316 of human BMP10 (NP_055297.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SPIM NLEQ SPLE EDMS LFGD VFSE QDGV DFNT LLQS MKDE FLKT LNLS DIPT QDSA KVDP PEYM LELY NKFA TDRT SMPS ANII RSFK NEDL FSQP VSFN GLRK YPLL FNVS IPHH EEVI MAEL RLYT LVQR DRMI YDGV DRKI TIFE VLES KGDN EGER NMLV LVSG EIYG TNSE WETF DVTD AIRR WQKS GSST HQLE VHIE SKHD EAED ASSG RLEI DTSA QNKH NPLL IVFS DDQS SDKE RKEE LNEM ISHE QLPE LDNL GLDS FSSG PGEE ALLQ MRSN IIYD STAR IRR |
| 遺伝子ID: | 27302 |
| Uniprot: | O95393 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 48kDa |
| 観察された分子量: | 48kDa |
| 同義語: | BMP10 |
| バックグラウンド: | The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. |
| UniProt Protein Function: | Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. |
| NCBI Summary: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016] |
| UniProt Code: | O95393 |
| NCBI GenInfo Identifier: | 13123977 |
| NCBI Gene ID: | 27302 |
| NCBI Accession: | O95393.1 |
| UniProt Secondary Accession: | O95393,Q53R17, Q6NTE0, |
| UniProt Related Accession: | O95393 |
| Molecular Weight: | 48,047 Da |
| NCBI Full Name: | Bone morphogenetic protein 10 |
| NCBI Synonym Full Names: | bone morphogenetic protein 10 |
| NCBI Official Symbol: | BMP10 |
| NCBI Protein Information: | bone morphogenetic protein 10 |
| UniProt Protein Name: | Bone morphogenetic protein 10 |
| Protein Family: | Bone morphogenetic protein |
| UniProt Gene Name: | BMP10 |
 | Western blot analysis of extracts of rat heart, using BMP10 antibody (CAB15010) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
View AllClose