Anti-BLOC1S1 Antibody (CAB13986)
- SKU:
- CAB13986
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-BLOC1S1 Antibody |
| 抗体コード: | CAB13986 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-153 of human BLOC1S1 (NP_001478.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-153 of human BLOC1S1 (NP_001478.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MLSR LLKE HQAK QNER KELQ EKRR REAI TAAT CLTE ALVD HLNV GVAQ AYMN QRKL DHEV KTLQ VQAA QFAK QTGQ WIGM VENF NQAL KEIG DVEN WARS IELD MRTI ATAL EYVY KGQL QSAP S |
| 遺伝子ID: | 2647 |
| Uniprot: | P78537 |
| セルラーロケーション: | Cytoplasm, Mitochondrion intermembrane space, Mitochondrion matrix, cytosol |
| 計算された分子量: | 14kDa/17kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | BLOC1S1, BLOS1, BORCS1, GCN5L1, MICoA, RT14 |
| バックグラウンド: |
| UniProt Protein Function: | BLOC1S1: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5A1 AND NDUFA9. May also be involved in the biogenesis of specialized organelles of the endosomal-lysosomal system. Belongs to the BLOC1S1 family. 2 isoforms of the human protein are produced by alternative initiation. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Vesicle Chromosomal Location of Human Ortholog: 12q13-q14 Cellular Component: extracellular space; lysosomal membrane; mitochondrial matrix; mitochondrial intermembrane space; cytosol Molecular Function:protein binding Biological Process: platelet dense granule organization and biogenesis; melanosome organization and biogenesis; anterograde synaptic vesicle transport; aerobic respiration; post-Golgi vesicle-mediated transport; anterograde axon cargo transport; peptidyl-lysine acetylation; neurite development |
| NCBI Summary: | BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004 [PubMed 15102850]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | P78537 |
| NCBI GenInfo Identifier: | 332278161 |
| NCBI Gene ID: | 2647 |
| NCBI Accession: | P78537.2 |
| UniProt Secondary Accession: | P78537,Q6NZ45, A1L4Q9, |
| UniProt Related Accession: | P78537 |
| Molecular Weight: | 153 |
| NCBI Full Name: | Biogenesis of lysosome-related organelles complex 1 subunit 1 |
| NCBI Synonym Full Names: | biogenesis of lysosomal organelles complex-1, subunit 1 |
| NCBI Official Symbol: | BLOC1S1 |
| NCBI Official Synonym Symbols: | RT14; BLOS1; MICoA; GCN5L1 |
| NCBI Protein Information: | biogenesis of lysosome-related organelles complex 1 subunit 1; BLOC subunit 1; BLOC-1 subunit 1; GCN5-like protein 1; MTA1-interacting coactivator; GCN5 general control of amino-acid synthesis 5-like 1; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 1 |
| UniProt Protein Name: | Biogenesis of lysosome-related organelles complex 1 subunit 1 |
| UniProt Synonym Protein Names: | GCN5-like protein 1; Protein RT14 |
| Protein Family: | Biogenesis of lysosome-related organelles complex |
| UniProt Gene Name: | BLOC1S1 |
| UniProt Entry Name: | BL1S1_HUMAN |
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