Anti-BHMT Antibody (CAB1216)

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SKU:
CAB1216
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
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Description

system_update_altデータシートsystem_update_alt安全性データシート
抗体名:Anti-BHMT Antibody
抗体コード:CAB1216
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 177-406 of human BHMT (NP_001704.2).
申し込み:WB IF
推奨希釈:WB 1:500 - 1:2000 IF 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:HL-60, Rat kidney
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 177-406 of human BHMT (NP_001704.2).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:SGKP VAAT MCIG PEGD LHGV PPGE CAVR LVKA GASI IGVN CHFD PTIS LKTV KLMK EGLE AARL KAHL MSQP LAYH TPDC NKQG FIDL PEFP FGLE PRVA TRWD IQKY AREA YNLG VRYI GGCC GFEP YHIR AIAE ELAP ERGF LPPA SEKH GSWG SGLD MHTK PWVR ARAR KEYW ENLR IASG RPYN PSMS KPDG WGVT KGTA ELMQ QKEA TTEQ QLKE LFEK QKFK SQ
遺伝子ID:635
Uniprot:Q93088
セルラーロケーション:Cytoplasm
計算された分子量:44kDa
観察された分子量:45kDa
同義語:BHMT, BHMT1, HEL-S-61p
バックグラウンド:This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed.
UniProt Protein Function:BHMT: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.5; Methyltransferase

Chromosomal Location of Human Ortholog: 5q14.1

Cellular Component: protein complex; cytoplasm; cytosol

Molecular Function:betaine-homocysteine S-methyltransferase activity; homocysteine S-methyltransferase activity; zinc ion binding; protein complex binding

Biological Process: S-methylmethionine cycle; protein amino acid methylation; betaine catabolic process; sulfur amino acid metabolic process; S-adenosylmethionine metabolic process; response to organic nitrogen; regulation of homocysteine metabolic process; betaine metabolic process

NCBI Summary:This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008]
UniProt Code:Q93088
NCBI GenInfo Identifier:145559446
NCBI Gene ID:635
NCBI Accession:Q93088.2
UniProt Secondary Accession:Q93088,O09171,
UniProt Related Accession:Q93088
Molecular Weight:45kDa
NCBI Full Name:Betaine--homocysteine S-methyltransferase 1
NCBI Synonym Full Names:betaine--homocysteine S-methyltransferase
NCBI Official Symbol:BHMT  
NCBI Official Synonym Symbols:BHMT1; HEL-S-61p  
NCBI Protein Information:betaine--homocysteine S-methyltransferase 1
UniProt Protein Name:Betaine--homocysteine S-methyltransferase 1
Protein Family:Betaine--homocysteine S-methyltransferase
UniProt Gene Name:BHMT  
UniProt Entry Name:BHMT1_HUMAN
Anti-BHMT Antibody (CAB1216)Western blot analysis of extracts of various cell lines, using BHMT antibody (CAB1216) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
Anti-BHMT Antibody (CAB1216)Immunofluorescence analysis of human liver cancer cells using BHMT antibody (CAB1216) at dilution of 1:100. Blue: DAPI for nuclear staining.
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