Anti-beta 2 Microglobulin Antibody (CAB12404)[KO Validated]
- SKU:
- CAB12404
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
抗体名: | Anti-beta 2 Microglobulin Antibody [KO Validated] |
抗体コード: | CAB12404 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IP |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-119 of human beta 2 Microglobulin (NP_004039.1). |
申し込み: | WB IHC IP |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Jurkat, COS7, HeLa, K-562, Mouse liver, Mouse spleen |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-119 of human beta 2 Microglobulin (NP_004039.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | IQRT PKIQ VYSR HPAE NGKS NFLN CYVS GFHP SDIE VDLL KNGE RIEK VEHS DLSF SKDW SFYL LYYT EFTP TEKD EYAC RVNH VTLS QPKI VKWD RDM |
遺伝子ID: | 567 |
Uniprot: | P61769 |
セルラーロケーション: | Secreted |
計算された分子量: | 13kDa |
観察された分子量: | 12kDa |
同義語: | B2M, IMD43 |
バックグラウンド: | This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia. |
UniProt Protein Function: | B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 15q21.1 Cellular Component: Golgi membrane; Golgi apparatus; extracellular space; phagocytic vesicle membrane; focal adhesion; membrane; early endosome membrane; endoplasmic reticulum lumen; cytoplasm; plasma membrane; extracellular region; MHC class I protein complex; external side of plasma membrane Molecular Function:identical protein binding; protein binding Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; iron ion homeostasis; antigen processing and presentation of peptide antigen via MHC class I; response to cadmium ion; response to molecule of bacterial origin; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Disease: Hypoproteinemia, Hypercatabolic |
NCBI Summary: | This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014] |
UniProt Code: | P61769 |
NCBI GenInfo Identifier: | 48428791 |
NCBI Gene ID: | 567 |
NCBI Accession: | P61769.1 |
UniProt Related Accession: | P61769 |
Molecular Weight: | |
NCBI Full Name: | Beta-2-microglobulin |
NCBI Synonym Full Names: | beta-2-microglobulin |
NCBI Official Symbol: | B2M |
NCBI Official Synonym Symbols: | IMD43 |
NCBI Protein Information: | beta-2-microglobulin |
UniProt Protein Name: | Beta-2-microglobulin |
Protein Family: | Beta-2-microglobulin |
UniProt Gene Name: | B2M |
UniProt Entry Name: | B2MG_HUMAN |