Anti-BDKRB2 Antibody (CAB2844)
- SKU:
- CAB2844
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-BDKRB2 Antibody |
| 抗体コード: | CAB2844 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 302-391 of human BDKRB2 (NP_000614.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549, MCF7, Mouse liver, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 302-391 of human BDKRB2 (NP_000614.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SSCQ DERI IDVI TQIA SFMA YSNS CLNP LVYV IVGK RFRK KSWE VYQG VCQK GGCR SEPI QMEN SMGT LRTS ISVE RQIH KLQD WAGS RQ |
| 遺伝子ID: | 624 |
| Uniprot: | P30411 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 41kDa/44kDa |
| 観察された分子量: | 44kDa |
| 同義語: | BDKRB2, B2R, BK-2, BK2, BKR2, BRB2 |
| バックグラウンド: | This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. |
| UniProt Protein Function: | BKR2: a receptor for bradykinin. Bradykinin elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral Chromosomal Location of Human Ortholog: 14q32.1-q32.2 Cellular Component: integral to plasma membrane; plasma membrane; endosome Molecular Function:bradykinin receptor activity; protein binding; protease binding; protein heterodimerization activity; type 1 angiotensin receptor binding; phosphoinositide phospholipase C activity Biological Process: vasoconstriction; metabolic process; blood circulation; negative regulation of peptidyl-serine phosphorylation; arachidonic acid secretion; vasodilation; response to salt stress; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; smooth muscle contraction; regulation of vasoconstriction; regulation of vascular permeability; inflammatory response; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30411 |
| NCBI GenInfo Identifier: | 2506481 |
| NCBI Gene ID: | 624 |
| NCBI Accession: | P30411.2 |
| UniProt Related Accession: | P30411 |
| Molecular Weight: | |
| NCBI Full Name: | B2 bradykinin receptor |
| NCBI Synonym Full Names: | bradykinin receptor B2 |
| NCBI Official Symbol: | BDKRB2 |
| NCBI Official Synonym Symbols: | B2R; BK2; BK-2; BKR2; BRB2 |
| NCBI Protein Information: | B2 bradykinin receptor |
| UniProt Protein Name: | B2 bradykinin receptor |
| UniProt Gene Name: | BDKRB2 |
| UniProt Entry Name: | BKRB2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BDKRB2 antibody (CAB2844) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunofluorescence analysis of HeLa cells using BDKRB2 Rabbit pAb (CAB2844) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of NIH/3T3 cells using BDKRB2 Rabbit pAb (CAB2844) at dilution of 1:100. Blue: DAPI for nuclear staining. |