Anti-BCAN Antibody (CAB9368)
- SKU:
- CAB9368
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-BCAN Antibody |
| 抗体コード: | CAB9368 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 762-911 of human BCAN (NP_068767.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | MCF7, K-562, Raji, HeLa, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 762-911 of human BCAN (NP_068767.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VPLL YENW NPGQ PDSY FLSG ENCV VMVW HDQG QWSD VPCN YHLS YTCK MGLV SCGP PPEL PLAQ VFGR PRLR YEVD TVLR YRCR EGLA QRNL PLIR CQEN GRWE APQI SCVP RRPA RALH PEED PEGR QGRL LGRW KALL IPPS SPMP GP |
| 遺伝子ID: | 63827 |
| Uniprot: | Q96GW7 |
| セルラーロケーション: | GPI-anchor, Lipid-anchor, Membrane, Secreted, extracellular matrix, extracellular space |
| 計算された分子量: | 71kDa/99kDa |
| 観察された分子量: | 110kDa |
| 同義語: | BCAN, BEHAB, CSPG7, brevican |
| バックグラウンド: | This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | BCAN: May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Belongs to the aggrecan/versican proteoglycan family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 1q31 Cellular Component: proteinaceous extracellular matrix; lysosomal lumen; Golgi lumen; extracellular region Molecular Function:extracellular matrix structural constituent; hyaluronic acid binding; carbohydrate binding Biological Process: extracellular matrix organization and biogenesis; central nervous system development; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; hippocampus development; pathogenesis; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; extracellular matrix disassembly; chondroitin sulfate catabolic process; carbohydrate metabolic process; cell adhesion; skeletal development |
| NCBI Summary: | This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q96GW7 |
| NCBI GenInfo Identifier: | 38372935 |
| NCBI Gene ID: | 63827 |
| NCBI Accession: | NP_068767.3 |
| UniProt Secondary Accession: | Q96GW7,Q5SZ10, Q5T3I5, Q8TBB9, Q9HBK1, Q9HBK4, D3DVC2 |
| UniProt Related Accession: | Q96GW7 |
| Molecular Weight: | |
| NCBI Full Name: | brevican core protein isoform 1 |
| NCBI Synonym Full Names: | brevican |
| NCBI Official Symbol: | BCAN |
| NCBI Official Synonym Symbols: | BEHAB; CSPG7 |
| NCBI Protein Information: | brevican core protein; chondroitin sulfate proteoglycan 7; chondroitin sulfate proteoglycan BEHAB; brain-enriched hyaluronan-binding protein |
| UniProt Protein Name: | Brevican core protein |
| UniProt Synonym Protein Names: | Brain-enriched hyaluronan-binding protein; BEHAB; Chondroitin sulfate proteoglycan 7 |
| Protein Family: | Brevican core protein |
| UniProt Gene Name: | BCAN |
| UniProt Entry Name: | PGCB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BCAN antibody (CAB9368) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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