Anti-BAZ2A / TIP5 Antibody (CAB17629)
- SKU:
- CAB17629
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
抗体名: | Anti-BAZ2A / TIP5 Antibody |
抗体コード: | CAB17629 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein of Human BAZ2A?TIP5?. |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | K-562, HeLa, NIH/3T3 |
免疫原: | Recombinant fusion protein of Human BAZ2A?TIP5?. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 11176 |
Uniprot: | Q9UIF9 |
セルラーロケーション: | |
計算された分子量: | |
観察された分子量: | 280kDa |
同義語: | TIP5, WALp3, BAZ2A / TIP5, BAZ2A |
バックグラウンド: |
UniProt Protein Function: | Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing. |
UniProt Code: | Q9UIF9 |
NCBI GenInfo Identifier: | 91176325 |
NCBI Gene ID: | 11176 |
NCBI Accession: | NP_038477.2 |
UniProt Secondary Accession: | Q9UIF9,O00536, O15030, Q68DI8, Q96H26, B3KN66, |
UniProt Related Accession: | Q9UIF9 |
Molecular Weight: | 210,747 Da |
NCBI Full Name: | bromodomain adjacent to zinc finger domain protein 2A isoform 1 |
NCBI Synonym Full Names: | bromodomain adjacent to zinc finger domain 2A |
NCBI Official Symbol: | BAZ2A |
NCBI Official Synonym Symbols: | TIP5; WALp3 |
NCBI Protein Information: | bromodomain adjacent to zinc finger domain protein 2A |
UniProt Protein Name: | Bromodomain adjacent to zinc finger domain protein 2A |
UniProt Synonym Protein Names: | Transcription termination factor I-interacting protein 5; TTF-I-interacting protein 5; Tip5; hWALp3 |
UniProt Gene Name: | BAZ2A |