Anti-BANK1 Antibody (CAB10312)
- SKU:
- CAB10312
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
抗体名: | Anti-BANK1 Antibody |
抗体コード: | CAB10312 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 516-785 of human BANK1 (NP_060405.4). |
申し込み: | WB |
推奨希釈: | WB 1:1000 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | B cells, Raji, U-87MG, A-549, 22Rv1, HepG2, Mouse liver, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 516-785 of human BANK1 (NP_060405.4). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | PVAN AFQL ERPH FTLP GTMV EGQM ERSQ NWGH PGVR QETG DEPK GEKE KKEE EKEQ EEEE DPYT FAEI DDSE YDMI LANL SIKK KTGS RSFI INRP PAPT PRPT SIPP KEET TPYI AQVF QQKT ARRQ SDDD KFRG LPKK QDRA RIES PAFS TLRG CLTD GQEE LILL QEKV KNGK MSMD EALE KFKH WQMG KSGL EMIQ QEKL RQLR DCII GKRP EEEN VYNK LTIV HHPG GKET AHNE NKFY NVHF SNKL PARP QVEK EFGF CCKK DH |
遺伝子ID: | 55024 |
Uniprot: | Q8NDB2 |
セルラーロケーション: | |
計算された分子量: | 73kDa/86kDa/88kDa/89kDa |
観察された分子量: | 89kDa |
同義語: | BANK1, BANK |
バックグラウンド: | The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1, 4, 5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | BANK1: Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. Genetic variations in BANK1 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 4q24 Disease: Systemic Lupus Erythematosus |
NCBI Summary: | The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q8NDB2 |
NCBI GenInfo Identifier: | 308153627 |
NCBI Gene ID: | 55024 |
NCBI Accession: | Q8NDB2.3 |
UniProt Secondary Accession: | Q8NDB2,Q8N5K8, Q8NB56, Q8WYN5, Q9NWP2, A8K7W8, B0F3S2 |
UniProt Related Accession: | Q8NDB2 |
Molecular Weight: | 73,674 Da |
NCBI Full Name: | B-cell scaffold protein with ankyrin repeats |
NCBI Synonym Full Names: | B-cell scaffold protein with ankyrin repeats 1 |
NCBI Official Symbol: | BANK1 |
NCBI Official Synonym Symbols: | BANK |
NCBI Protein Information: | B-cell scaffold protein with ankyrin repeats |
UniProt Protein Name: | B-cell scaffold protein with ankyrin repeats |
Protein Family: | B-cell scaffold protein with ankyrin repeats |
UniProt Gene Name: | BANK1 |
UniProt Entry Name: | BANK1_HUMAN |
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