Anti-BAMBI Antibody (CAB6532)
- SKU:
- CAB6532
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-BAMBI Antibody |
| 抗体コード: | CAB6532 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-152 of human BAMBI (NP_036474.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | A-549, Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-152 of human BAMBI (NP_036474.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VLLT KGEI RCYC DAAH CVAT GYMC KSEL SACF SRLL DPQN SNSP LTHG CLDS LAST TDIC QAKQ ARNH SGTT IPTL ECCH EDMC NYRG LHDV LSPP RGEA SGQG NRYQ HDGS RNLI TKVQ ELTS SKEL WFRA |
| 遺伝子ID: | 25805 |
| Uniprot: | Q13145 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 29kDa |
| 観察された分子量: | 55kDa |
| 同義語: | BAMBI, NMA |
| バックグラウンド: | This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. |
| UniProt Protein Function: | BAMBI: Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Inhibitor Chromosomal Location of Human Ortholog: 10p12.3-p11.2 Cellular Component: cytoplasm; integral to membrane; plasma membrane Molecular Function:frizzled binding; punt binding Biological Process: regulation of cell shape; cell migration; positive regulation of protein binding; positive regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway |
| NCBI Summary: | This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13145 |
| NCBI GenInfo Identifier: | 2498645 |
| NCBI Gene ID: | 25805 |
| NCBI Accession: | Q13145.1 |
| UniProt Related Accession: | Q13145 |
| Molecular Weight: | 260 |
| NCBI Full Name: | BMP and activin membrane-bound inhibitor homolog |
| NCBI Synonym Full Names: | BMP and activin membrane-bound inhibitor |
| NCBI Official Symbol: | BAMBI |
| NCBI Official Synonym Symbols: | NMA |
| NCBI Protein Information: | BMP and activin membrane-bound inhibitor homolog; non-metastatic gene A protein; putative transmembrane protein NMA |
| UniProt Protein Name: | BMP and activin membrane-bound inhibitor homolog |
| UniProt Synonym Protein Names: | Non-metastatic gene A protein; Putative transmembrane protein NMA |
| Protein Family: | BMP and activin membrane-bound inhibitor |
| UniProt Gene Name: | BAMBI |
| UniProt Entry Name: | BAMBI_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BAMBI antibody (CAB6532) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of HeLa cells using BAMBI antibody (CAB6532). Blue: DAPI for nuclear staining. |
View AllClose