Anti-BAG4 Antibody (CAB17052)
- SKU:
- CAB17052
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-BAG4 Antibody |
| 抗体コード: | CAB17052 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BAG4 (NP_001191807.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BAG4 (NP_001191807.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSAL RRSG YGPS DGPS YGRY YGPG GGDV PVHP PPPL YPLR PEPP QPPI SWRV RGGG PAET TWLG EGGG GDGY YPSG GAWP EPGR AGGS HQSL NSYT NGAY |
| 遺伝子ID: | 9530 |
| Uniprot: | O95429 |
| セルラーロケーション: | |
| 計算された分子量: | 45kDa/49kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | BAG4, BAG-4, SODD |
| バックグラウンド: | The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. |
| UniProt Protein Function: | BAG4: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 8p11.23 Cellular Component: cytosol; nucleus; plasma membrane Molecular Function:adenyl-nucleotide exchange factor activity; protein binding; receptor signaling protein activity; ubiquitin protein ligase binding Biological Process: negative regulation of apoptosis; protein folding; tumor necrosis factor-mediated signaling pathway |
| NCBI Summary: | The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011] |
| UniProt Code: | O95429 |
| NCBI GenInfo Identifier: | 12643661 |
| NCBI Gene ID: | 9530 |
| NCBI Accession: | O95429.1 |
| UniProt Secondary Accession: | O95429,O95818, B4E217, |
| UniProt Related Accession: | O95429 |
| Molecular Weight: | 45,410 Da |
| NCBI Full Name: | BAG family molecular chaperone regulator 4 |
| NCBI Synonym Full Names: | BCL2 associated athanogene 4 |
| NCBI Official Symbol: | BAG4 |
| NCBI Official Synonym Symbols: | SODD; BAG-4 |
| NCBI Protein Information: | BAG family molecular chaperone regulator 4 |
| UniProt Protein Name: | BAG family molecular chaperone regulator 4 |
| UniProt Synonym Protein Names: | Bcl-2-associated athanogene 4; Silencer of death domains |
| Protein Family: | BAG family molecular chaperone regulator |
| UniProt Gene Name: | BAG4 |
 | Western blot analysis of extracts of various cell lines, using BAG4 antibody (CAB17052) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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