Anti-ATP6V0D1 Antibody (CAB4271)
- SKU:
- CAB4271
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
抗体名: | Anti-ATP6V0D1 Antibody |
抗体コード: | CAB4271 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human ATP6V0D1 (NP_004682.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human ATP6V0D1 (NP_004682.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSFF PELY FNVD NGYL EGLV RGLK AGVL SQAD YLNL VQCE TLED LKLH LQST DYGN FLAN EASP LTVS VIDD RLKE KMVV EFRH MRNH AYEP LASF LDFI TYSY MIDN VILL ITGT LHQR SIAE LVPK CHPL GSFE QMEA VNIA QTPA ELYN AILV DTPL AAFF QDCI SEQD LDEM NIEI IRNT LYKA YLES FYKF CTLL GGTT ADAM CPIL EFEA DRRA FIIT INSF GTEL SKED RAKL FPHC GRLY PEGL AQLA RADD YEQV KNVA DYYP EYKL LFEG AGSN PGDK TLED RFFE HEVK LNKL AFLN QFHF GVFY AFVK LKEQ ECRN IVWI AECI AQRH RAKI DNYI PIF |
遺伝子ID: | 9114 |
Uniprot: | P61421 |
セルラーロケーション: | Cytoplasmic side, Membrane, Peripheral membrane protein |
計算された分子量: | 40kDa |
観察された分子量: | 40kDa |
同義語: | ATP6V0D1, ATP6D, ATP6DV, P39, VATX, VMA6, VPATPD |
バックグラウンド: | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. |
UniProt Protein Function: | ATP6V0D1: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. Belongs to the V-ATPase V0D/AC39 subunit family. |
UniProt Protein Details: | Protein type:Hydrolase; Vesicle; EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: centrosome; phagocytic vesicle membrane; synaptic vesicle; membrane; lysosomal membrane; apical plasma membrane; early endosome; endosome membrane; vacuolar proton-transporting V-type ATPase complex; nerve terminal Molecular Function:hydrogen-exporting ATPase activity, phosphorylative mechanism; protein binding; protein complex binding Biological Process: interaction with host; proton transport; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; cilium biogenesis; brain development; transmembrane transport |
NCBI Summary: | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008] |
UniProt Code: | P61421 |
NCBI GenInfo Identifier: | 47606646 |
NCBI Gene ID: | 9114 |
NCBI Accession: | P61421.1 |
UniProt Secondary Accession: | P61421,P12953, Q02547, |
UniProt Related Accession: | P61421 |
Molecular Weight: | 351 |
NCBI Full Name: | V-type proton ATPase subunit d 1 |
NCBI Synonym Full Names: | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 |
NCBI Official Symbol: | ATP6V0D1 |
NCBI Official Synonym Symbols: | P39; VATX; VMA6; ATP6D; ATP6DV; VPATPD |
NCBI Protein Information: | V-type proton ATPase subunit d 1; V-ATPase, subunit D; V-ATPase subunit d 1; V-ATPase AC39 subunit; 32 kDa accessory protein; vacuolar proton pump subunit d 1; V-ATPase 40 KDa accessory protein; H(+)-transporting two-sector ATPase, subunit D; ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D |
UniProt Protein Name: | V-type proton ATPase subunit d 1 |
UniProt Synonym Protein Names: | 32 kDa accessory protein; V-ATPase 40 kDa accessory protein; V-ATPase AC39 subunit; p39; Vacuolar proton pump subunit d 1 |
Protein Family: | V-type proton ATPase |
UniProt Gene Name: | ATP6V0D1 |
UniProt Entry Name: | VA0D1_HUMAN |