Anti-ATP2C1 Antibody (CAB2515)
- SKU:
- CAB2515
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ATP2C1 Antibody |
| 抗体コード: | CAB2515 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-660 of human ATP2C1 (NP_001186114.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Raji, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-660 of human ATP2C1 (NP_001186114.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AVSR IVEA GCVC NDAV IRNN TLMG KPTE GALI ALAM KMGL DGLQ QDYI RKAE YPFS SEQK WMAV KCVH RTQQ DRPE ICFM KGAY EQVI KYCT TYQS KGQT LTLT QQQR DVYQ QEKA RMGS AGLR VLAL ASGP ELGQ LTFL GLVG IIDP PRTG VKEA VTTL IASG VSIK MITG DSQE TAVA IASR LGLY SKTS QSVS GEEI DAMD VQQL SQIV PKVA VFYR ASPR HKMK IIKS LQKN GSVV AMTG DGVN DAVA LKAA DIGV A |
| 遺伝子ID: | 27032 |
| Uniprot: | P98194 |
| セルラーロケーション: | Golgi apparatus membrane, Multi-pass membrane protein |
| 計算された分子量: | 96- 107kDa |
| 観察された分子量: | 125kDa |
| 同義語: | ATP2C1, ATP2C1A, BCPM, HHD, PMR1, SPCA1, hSPCA1 |
| バックグラウンド: | The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | ATP2C1: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD); also known as benign familial pemphigus. HHD is an autosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter; Hydrolase; Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel; EC 3.6.3.8 Chromosomal Location of Human Ortholog: 3q22.1 Cellular Component: Golgi membrane; Golgi apparatus; membrane; integral to membrane; trans-Golgi network Molecular Function:manganese-transporting ATPase activity; signal transducer activity; calcium-transporting ATPase activity; manganese ion binding; metal ion binding; calcium ion binding; ATP binding Biological Process: cellular calcium ion homeostasis; Golgi calcium ion homeostasis; epidermis development; positive regulation of I-kappaB kinase/NF-kappaB cascade; metabolic process; calcium ion transport; calcium-dependent cell-cell adhesion; actin cytoskeleton reorganization; manganese ion transport; cellular manganese ion homeostasis; signal transduction; Golgi calcium ion transport; transmembrane transport Disease: Benign Chronic Pemphigus |
| NCBI Summary: | The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P98194 |
| NCBI GenInfo Identifier: | 68068024 |
| NCBI Gene ID: | 27032 |
| NCBI Accession: | P98194.3 |
| UniProt Secondary Accession: | P98194,O76005, Q86V72, Q86V73, Q8N6V1, Q8NCJ7, B2RAT7 B4DSW3, B7Z3X9, G3XAH8, G8JLN9, |
| UniProt Related Accession: | P98194 |
| Molecular Weight: | 919 |
| NCBI Full Name: | Calcium-transporting ATPase type 2C member 1 |
| NCBI Synonym Full Names: | ATPase, Ca++ transporting, type 2C, member 1 |
| NCBI Official Symbol: | ATP2C1 |
| NCBI Official Synonym Symbols: | HHD; BCPM; PMR1; SPCA1; hSPCA1; ATP2C1A |
| NCBI Protein Information: | calcium-transporting ATPase type 2C member 1; HUSSY-28; ATPase 2C1; ATPase, Ca(2+)-sequestering; ATP-dependent Ca(2+) pump PMR1; secretory pathway Ca2+/Mn2+ ATPase 1 |
| UniProt Protein Name: | Calcium-transporting ATPase type 2C member 1 |
| UniProt Synonym Protein Names: | ATP-dependent Ca(2+) pump PMR1 |
| Protein Family: | Calcium-transporting ATPase |
| UniProt Gene Name: | ATP2C1 |
| UniProt Entry Name: | AT2C1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ATP2C1 Antibody (CAB2515) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded mouse lung using ATP2C1 antibody (CAB2515) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat brain using ATP2C1 antibody (CAB2515) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using ATP2C1 antibody (CAB2515) at dilution of 1:100 (40x lens). |
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