Anti-ATP1A3 Antibody (CAB16036)
- SKU:
- CAB16036
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-ATP1A3 Antibody |
| 抗体コード: | CAB16036 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human ATP1A3 (NP_689509.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse liver, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human ATP1A3 (NP_689509.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGDK KDDK DSPK KNKG KERR DLDD LKKE VAMT EHKM SVEE VCRK YNTD CVQG LTHS KAQE |
| 遺伝子ID: | 478 |
| Uniprot: | P13637 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 111kDa/113kDa |
| 観察された分子量: | 112kDa |
| 同義語: | ATP1A3, AHC2, ATP1A1, CAPOS, DYT12, RDP |
| バックグラウンド: | The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ATP1A3: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Defects in ATP1A3 are the cause of dystonia type 12 (DYT12); also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant dystonia- parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT12 patients develop dystonia and parkinsonism between 15 and 45 years of age. The disease is characterized by an unusually rapid evolution of signs and symptoms. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. |
| UniProt Protein Details: | Protein type:Transporter; Endoplasmic reticulum; Membrane protein, multi-pass; Hydrolase; Transporter, ion channel; Membrane protein, integral; EC 3.6.3.9 Chromosomal Location of Human Ortholog: 19q13.31 Cellular Component: endoplasmic reticulum; Golgi apparatus; plasma membrane; sodium:potassium-exchanging ATPase complex; synapse Molecular Function:chaperone binding; sodium:potassium-exchanging ATPase activity Biological Process: ATP hydrolysis coupled proton transport; cellular potassium ion homeostasis; cellular sodium ion homeostasis; potassium ion import Disease: Alternating Hemiplegia Of Childhood 2; Cerebellar Ataxia, Areflexia, Pes Cavus, Optic Atrophy, And Sensorineural Hearing Loss; Dystonia 12 |
| NCBI Summary: | The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P13637 |
| NCBI GenInfo Identifier: | 116241260 |
| NCBI Gene ID: | 478 |
| NCBI Accession: | P13637.3 |
| UniProt Secondary Accession: | P13637,Q16732, Q16735, Q969K5, B7Z2T0, B7Z401, F5H6J6 |
| UniProt Related Accession: | P13637 |
| Molecular Weight: | 113,059 Da |
| NCBI Full Name: | Sodium/potassium-transporting ATPase subunit alpha-3 |
| NCBI Synonym Full Names: | ATPase Na+/K+ transporting subunit alpha 3 |
| NCBI Official Symbol: | ATP1A3 |
| NCBI Official Synonym Symbols: | RDP; AHC2; CAPOS; DYT12; ATP1A1 |
| NCBI Protein Information: | sodium/potassium-transporting ATPase subunit alpha-3 |
| UniProt Protein Name: | Sodium/potassium-transporting ATPase subunit alpha-3 |
| UniProt Synonym Protein Names: | Na(+)/K(+) ATPase alpha(III) subunit; Sodium pump subunit alpha-3 |
| Protein Family: | Sodium/potassium-transporting ATPase |
| UniProt Gene Name: | ATP1A3 |
| UniProt Entry Name: | AT1A3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ATP1A3 antibody (CAB16036) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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