Anti-ATOH7 Antibody (CAB7273)
- SKU:
- CAB7273
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| 抗体名: | Anti-ATOH7 Antibody |
| 抗体コード: | CAB7273 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 47-152 of human ATOH7 (NP_660161.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 47-152 of human ATOH7 (NP_660161.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ARER RRMQ GLNT AFDR LRRV VPQW GQDK KLSK YETL QMAL SYIM ALTR ILAE AERF GSER DWVG LHCE HFGR DHYL PFPG AKLP GESE LYSQ RLFG FQPE PFQM AT |
| 遺伝子ID: | 220202 |
| Uniprot: | Q8N100 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 16kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | ATOH7, Math5, NCRNA, PHPVAR, RNANC, bHLHa13 |
| バックグラウンド: | This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic congenital retinal nonattachment. |
| UniProt Protein Function: | ATOH7: Transcription factor involved in the differentiation of retinal ganglion cells. Defects in ATOH7 are the cause of retinal non-attachment congenital non-syndromic (RNANC). A condition characterized by separation of the inner layers of the retina (neural retina) from the pigment epithelium. Clinical findings include lack of perception of light, massive retrolental mass, shallow anterior chamber, and nystagmus in otherwise normal individuals. RNANC is caused by a 6.5 kb deletion that spans a remote cis regulatory element 20 kb upstream from ATOH7. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 10q21.3|10q21.3-q22.1 Cellular Component: nucleus Molecular Function:protein dimerization activity; DNA binding Biological Process: circadian rhythm; transcription, DNA-dependent; regulation of transcription, DNA-dependent; optic nerve development; entrainment of circadian clock; cell differentiation Disease: Persistent Hyperplastic Primary Vitreous, Autosomal Recessive |
| NCBI Summary: | This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic congenital retinal nonattachment. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q8N100 |
| NCBI GenInfo Identifier: | 74750873 |
| NCBI Gene ID: | 220202 |
| NCBI Accession: | Q8N100.1 |
| UniProt Related Accession: | Q8N100 |
| Molecular Weight: | 152 |
| NCBI Full Name: | Protein atonal homolog 7 |
| NCBI Synonym Full Names: | atonal homolog 7 (Drosophila) |
| NCBI Official Symbol: | ATOH7 |
| NCBI Official Synonym Symbols: | Math5; NCRNA; RNANC; PHPVAR; bHLHa13 |
| NCBI Protein Information: | protein atonal homolog 7; helix-loop-helix protein hATH-5; class A basic helix-loop-helix protein 13 |
| UniProt Protein Name: | Protein atonal homolog 7 |
| UniProt Synonym Protein Names: | Class A basic helix-loop-helix protein 13; bHLHa13; Helix-loop-helix protein hATH-5; hATH5 |
| Protein Family: | Protein atonal |
| UniProt Gene Name: | ATOH7 |
| UniProt Entry Name: | ATOH7_HUMAN |
 | Immunofluorescence analysis of A-549 cells using ATOH7 antibody (CAB7273). |
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