Anti-ATF7IP Antibody (CAB10446)
- SKU:
- CAB10446
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-ATF7IP Antibody |
| 抗体コード: | CAB10446 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IHC |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 525-725 of human ATF7IP (NP_060649.3). |
| 申し込み: | IHC |
| 推奨希釈: | IHC 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 525-725 of human ATF7IP (NP_060649.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NEKD NKPE EEEQ VIHE DDER PSEK NEFS RRKR SKSE DMDN VQSK RRRY MEEE YEAE FQVK ITAK GDIN QKLQ KVIQ WLLE EKLC ALQC AVFD KTLA ELKT RVEK IECN KRHK TVLT ELQA KIAR LTKR FEAA KEDL KKRH EHPP NPPV SPGK TVND VNSN NNMS YRNA GTVR QMLE SKRN VSES APPS FQTP VNTV SSTN L |
| 遺伝子ID: | 55729 |
| Uniprot: | Q6VMQ6 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 118kDa/136kDa/137kDa |
| 観察された分子量: |
| 同義語: | ATF7IP, AM, ATF-IP, MCAF, MCAF1, p621 |
| バックグラウンド: |
| UniProt Protein Function: | ATF7IP: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells. Belongs to the MCAF family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 12p13.1 Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus Molecular Function:protein binding; ATPase activity; transcription corepressor activity Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; viral reproduction; positive regulation of transcription, DNA-dependent; DNA methylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of transcriptional preinitiation complex assembly |
| NCBI Summary: | ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010] |
| UniProt Code: | Q6VMQ6 |
| NCBI GenInfo Identifier: | 29611342 |
| NCBI Gene ID: | 55729 |
| NCBI Accession: | AAO91864.1 |
| UniProt Secondary Accession: | Q6VMQ6,Q4G0T9, Q6P3T3, Q86XW5, Q9NVJ9, Q9NWC2, Q9Y4X8 F5GX74, G3V1U0, |
| UniProt Related Accession: | Q6VMQ6 |
| Molecular Weight: | 136,323 Da |
| NCBI Full Name: | MBD1-containing chromatin associated factor |
| NCBI Synonym Full Names: | activating transcription factor 7 interacting protein |
| NCBI Official Symbol: | ATF7IP |
| NCBI Official Synonym Symbols: | AM; MCAF; p621; MCAF1; ATF-IP |
| NCBI Protein Information: | activating transcription factor 7-interacting protein 1 |
| UniProt Protein Name: | Activating transcription factor 7-interacting protein 1 |
| UniProt Synonym Protein Names: | ATF-interacting protein; ATF-IP; ATF7-interacting protein; ATFa-associated modulator; hAM; MBD1-containing chromatin-associated factor 1; P621 |
| UniProt Gene Name: | ATF7IP |
| UniProt Entry Name: | MCAF1_HUMAN |
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