| UniProt Protein Function: | ATF-4: a transcription factor that is a member of the leucine zipper family. Isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). Involved in cisplatin resistance. Other members of the family include AP-1 transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: nucleoplasm; neuron projection; cytoplasm; microtubule organizing center; nucleus Molecular Function:protein C-terminus binding; leucine zipper domain binding; protein binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity Biological Process: amino acid metabolic process; transcription from RNA polymerase II promoter; positive regulation of apoptosis; unfolded protein response; positive regulation of transcription, DNA-dependent; negative regulation of potassium ion transport; positive regulation of transcription from RNA polymerase I promoter; gluconeogenesis; cellular response to glucose starvation; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; regulation of transcription, DNA-dependent; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; gamma-aminobutyric acid signaling pathway |
| NCBI Summary: | This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011] |
| UniProt Code: | P18848 |
| NCBI GenInfo Identifier: | 116241262 |
| NCBI Gene ID: | 468 |
| NCBI Accession: | P18848.3 |
| UniProt Secondary Accession: | P18848,Q9UH31, |
| UniProt Related Accession: | P18848 |
| Molecular Weight: | Calculated Molecular Weight: 38kDaObserved Molecular Weight: 38kDa |
| NCBI Full Name: | Cyclic AMP-dependent transcription factor ATF-4 |
| NCBI Synonym Full Names: | activating transcription factor 4 |
| NCBI Official Symbol: | ATF4 |
| NCBI Official Synonym Symbols: | CREB2; TXREB; CREB-2; TAXREB67 |
| NCBI Protein Information: | cyclic AMP-dependent transcription factor ATF-4; DNA-binding protein TAXREB67; tax-responsive enhancer element B67; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; cyclic AMP-responsive element-binding protein 2; tax-responsive enhancer element-binding protein 67 |
| UniProt Protein Name: | Cyclic AMP-dependent transcription factor ATF-4 |
| UniProt Synonym Protein Names: | Activating transcription factor 4; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; Tax-responsive enhancer element-binding protein 67; TaxREB67 |
| Protein Family: | Cyclic AMP-dependent transcription factor |
| UniProt Gene Name: | ATF4 |
| UniProt Entry Name: | ATF4_HUMAN |
