Anti-ASIP Antibody (CAB13280)
- SKU:
- CAB13280
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ASIP Antibody |
| 抗体コード: | CAB13280 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-132 of human ASIP (NP_001663.2). |
| 申し込み: | IF |
| 推奨希釈: | IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-132 of human ASIP (NP_001663.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | HLPP EEKL RDDR SLRS NSSV NLLD VPSV SIVA LNKK SKQI GRKA AEKK RSSK KEAS MKKV VRPR TPLS APCV ATRN SCKP PAPA CCDP CASC QCRF FRSA CSCR VLSL NC |
| 遺伝子ID: | 434 |
| Uniprot: | P42127 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 14kDa |
| 観察された分子量: |
| 同義語: | ASIP, AGSW, AGTI, AGTIL, ASP, SHEP9 |
| バックグラウンド: | In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. |
| UniProt Protein Function: | ASIP: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 20q11.2-q12 Cellular Component: extracellular space Molecular Function:type 3 melanocortin receptor binding; type 4 melanocortin receptor binding; receptor binding Biological Process: melanin biosynthetic process; generation of precursor metabolites and energy; regulation of molecular function, epigenetic; hormone-mediated signaling; cell-cell signaling; melanosome organization and biogenesis; adult feeding behavior; signal transduction; melanosome transport Disease: Skin/hair/eye Pigmentation, Variation In, 9 |
| NCBI Summary: | In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P42127 |
| NCBI GenInfo Identifier: | 1168389 |
| NCBI Gene ID: | 434 |
| NCBI Accession: | P42127.1 |
| UniProt Secondary Accession: | P42127,Q3SXL2, |
| UniProt Related Accession: | P42127 |
| Molecular Weight: | 132 |
| NCBI Full Name: | Agouti-signaling protein |
| NCBI Synonym Full Names: | agouti signaling protein |
| NCBI Official Symbol: | ASIP |
| NCBI Official Synonym Symbols: | ASP; AGSW; AGTI; AGTIL; SHEP9 |
| NCBI Protein Information: | agouti-signaling protein; nonagouti homolog; agouti switch protein; agouti signaling protein, nonagouti homolog |
| UniProt Protein Name: | Agouti-signaling protein |
| UniProt Synonym Protein Names: | Agouti switch protein |
| Protein Family: | Agouti-signaling protein |
| UniProt Gene Name: | ASIP |
| UniProt Entry Name: | ASIP_HUMAN |
 | Immunofluorescence analysis of HeLa cells using ASIP antibody (CAB13280). Blue: DAPI for nuclear staining. |
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