| UniProt Protein Function: | ASB3: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2p16.2 Molecular Function:protein binding |
| NCBI Summary: | This locus represents naturally occurring read-through transcription between the neighboring GPR75 (G protein-coupled receptor 75) and ASB3 (ankyrin repeat and SOCS box containing 3) on chromosome 2. The transcript includes exons from both GPR75 and ASB3 and translation initiates in the 5' non-coding exon of GPR75. The resulting protein has a novel N-terminus but is otherwise identical to that encoded by ASB3.[provided by RefSeq, Feb 2011] |
| UniProt Code: | Q9Y575 |
| NCBI GenInfo Identifier: | 20532004 |
| NCBI Gene ID: | 100302652 |
| NCBI Accession: | Q9Y575.1 |
| UniProt Secondary Accession: | Q9Y575,Q2TAI4, Q53TN0, Q53TN8, Q9NVZ2, B3KPA3, D6W5B4 D6W5B5, G8JLA9, |
| Molecular Weight: | 61,775 Da |
| NCBI Full Name: | Ankyrin repeat and SOCS box protein 3 |
| NCBI Synonym Full Names: | GPR75-ASB3 readthrough |
| NCBI Official Symbol: | GPR75-ASB3 |
| NCBI Protein Information: | GPR75-ASB3 protein |
| UniProt Protein Name: | Ankyrin repeat and SOCS box protein 3 |
| Protein Family: | Ankyrin repeat and SOCS box protein |
| UniProt Gene Name: | ASB3 |
| UniProt Entry Name: | ASB3_HUMAN |
