| UniProt Protein Function: | ASB2: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 14q31-q32 Molecular Function:protein binding Biological Process: positive regulation of defense response to virus by host; signal transduction |
| NCBI Summary: | This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
| UniProt Code: | Q96Q27 |
| NCBI GenInfo Identifier: | 20531999 |
| NCBI Gene ID: | 51676 |
| NCBI Accession: | Q96Q27.1 |
| UniProt Secondary Accession: | Q96Q27,Q9NSU5, Q9Y567, B2RDP9, B4E166, |
| UniProt Related Accession: | Q96Q27 |
| Molecular Weight: | 70,212 Da |
| NCBI Full Name: | Ankyrin repeat and SOCS box protein 2 |
| NCBI Synonym Full Names: | ankyrin repeat and SOCS box containing 2 |
| NCBI Official Symbol: | ASB2 |
| NCBI Official Synonym Symbols: | ASB-2 |
| NCBI Protein Information: | ankyrin repeat and SOCS box protein 2 |
| UniProt Protein Name: | Ankyrin repeat and SOCS box protein 2 |
| Protein Family: | Anthranilate synthase |
| UniProt Gene Name: | ASB2 |
| UniProt Entry Name: | ASB2_HUMAN |
