| 同義語: | AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1, ASAP2 |
| バックグラウンド: | This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
| NCBI Summary: | This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
| UniProt Code: | O43150 |
| NCBI GenInfo Identifier: | 4502249 |
| NCBI Gene ID: | 8853 |
| NCBI Accession: | NP_003878 |
| UniProt Related Accession: | O43150 |
| Molecular Weight: | 112kDa |
| NCBI Full Name: | arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform a |
| NCBI Synonym Full Names: | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 |
| NCBI Official Symbol: | ASAP2 |
| NCBI Official Synonym Symbols: | PAP; PAG3; AMAP2; DDEF2; SHAG1; CENTB3; Pap-alpha |
| NCBI Protein Information: | arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 |
| UniProt Protein Name: | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 |
| UniProt Synonym Protein Names: | Development and differentiation-enhancing factor 2; Paxillin-associated protein with ARF GAP activity 3; PAG3; Pyk2 C-terminus-associated protein; PAP |
| Protein Family: | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein |
| UniProt Gene Name: | ASAP2 |
| UniProt Entry Name: | ASAP2_HUMAN |
