Anti-AS3MT Antibody (CAB16138)
- SKU:
- CAB16138
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-AS3MT Antibody |
| 抗体コード: | CAB16138 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 216-375 of human AS3MT (NP_065733.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse spleen |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 216-375 of human AS3MT (NP_065733.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LAVL AQKI GFCP PRLV TANL ITIQ NKEL ERVI GDCR FVSA TFRL FKHS KTGP TKRC QVIY NGGI TGHE KELM FDAN FTFK EGEI VEVD EETA AILK NSRF AQDF LIRP IGEK LPTS GGCS ALEL KDII TDPF KLAE ESDS MKSR CVPD AAGG CCGT KKSC |
| 遺伝子ID: | 57412 |
| Uniprot: | Q9HBK9 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 31kDa/41kDa |
| 観察された分子量: | 42kDa |
| 同義語: | AS3MT, CYT19 |
| バックグラウンド: | AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism. |
| UniProt Protein Function: | AS3MT: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. Belongs to the methyltransferase superfamily. |
| UniProt Protein Details: | Protein type:EC 2.1.1.137; Methyltransferase; Mitochondrial Chromosomal Location of Human Ortholog: 10q24.32 Cellular Component: mitochondrion; cytoplasm; cytosol Molecular Function:arsenite methyltransferase activity; methylarsonite methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity Biological Process: methylation; arsonoacetate metabolic process; toxin metabolic process |
| NCBI Summary: | AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9HBK9 |
| NCBI GenInfo Identifier: | 109389364 |
| NCBI Gene ID: | 57412 |
| NCBI Accession: | NP_065733.2 |
| UniProt Secondary Accession: | Q9HBK9,Q0VDK3, Q0VDK4, Q5PZ02, A6NP79, |
| UniProt Related Accession: | Q9HBK9 |
| Molecular Weight: | 31,098 Da |
| NCBI Full Name: | arsenite methyltransferase |
| NCBI Synonym Full Names: | arsenite methyltransferase |
| NCBI Official Symbol: | AS3MT |
| NCBI Official Synonym Symbols: | CYT19 |
| NCBI Protein Information: | arsenite methyltransferase; methyltransferase cyt19; methylarsonite methyltransferase; arsenic (+3 oxidation state) methyltransferase; S-adenosylmethionine:arsenic (III) methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase |
| UniProt Protein Name: | Arsenite methyltransferase |
| UniProt Synonym Protein Names: | Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase |
| Protein Family: | Arsenite methyltransferase |
| UniProt Gene Name: | AS3MT |
| UniProt Entry Name: | AS3MT_HUMAN |
 | Western blot analysis of extracts of mouse spleen, using AS3MT antibody (CAB16138) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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