Anti-ARSE Antibody (CAB15644)
- SKU:
- CAB15644
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ARSE Antibody |
| 抗体コード: | CAB15644 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 520-589 of human ARSE (NP_000038.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse liver, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 520-589 of human ARSE (NP_000038.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | PSET HILT PASE PVFY QVME RVQQ AVWE HQRT LSPV PLQL DRLG NIWR PWLQ PCCG PFPL CWCL REDD PQ |
| 遺伝子ID: | 415 |
| Uniprot: | P51690 |
| セルラーロケーション: | Golgi apparatus, Golgi stack |
| 計算された分子量: | 65kDa |
| 観察された分子量: | 75kDa |
| 同義語: | ARSE, ASE, CDPX, CDPX1, CDPXR |
| バックグラウンド: | Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome. |
| UniProt Protein Function: | ARSE: May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates. Defects in ARSE are the cause of chondrodysplasia punctata X-linked recessive type 1 (CDPX1). CDP is a clinically and genetically heterogeneous disorder characterized by punctiform calcification of the bones. CDPX1 is a congenital defect of bone and cartilage development characterized by aberrant bone mineralization, severe underdevelopment of nasal cartilage, and distal phalangeal hypoplasia. This disease can also be induced by inhibition with the drug warfarin. Belongs to the sulfatase family. |
| UniProt Protein Details: | Protein type:Hydrolase; EC 3.1.6.- Chromosomal Location of Human Ortholog: Xp22.3 Cellular Component: Golgi stack; endoplasmic reticulum lumen Molecular Function:arylsulfatase activity; metal ion binding Biological Process: cellular protein metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; post-translational protein modification; skeletal development Disease: Chondrodysplasia Punctata 1, X-linked Recessive |
| NCBI Summary: | Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome. [provided by RefSeq, Sep 2013] |
| UniProt Code: | P51690 |
| NCBI GenInfo Identifier: | 157266309 |
| NCBI Gene ID: | 415 |
| NCBI Accession: | NP_000038.2 |
| UniProt Related Accession: | P51690 |
| Molecular Weight: | |
| NCBI Full Name: | arylsulfatase L isoform 2 |
| NCBI Synonym Full Names: | arylsulfatase L |
| NCBI Official Symbol: | ARSL |
| NCBI Official Synonym Symbols: | ASE; ARSE; CDPX; CDPX1; CDPXR |
| NCBI Protein Information: | arylsulfatase L; arylsulfatase E |
| UniProt Protein Name: | Arylsulfatase E |
| Protein Family: | Arylsulfatase |
| UniProt Gene Name: | ARSE |
| UniProt Entry Name: | ARSE_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ARSE antibody (CAB15644) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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