Anti-ARPC1B Antibody (CAB17070)
- SKU:
- CAB17070
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-ARPC1B Antibody |
| 抗体コード: | CAB17070 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 10-80 of human ARPC1B (NP_005711.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 10-80 of human ARPC1B (NP_005711.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | PISC HAWN KDRT QIAI CPNN HEVH IYEK SGAK WTKV HELK EHNG QVTG IDWA PESN RIVT CGTD RNAY VWT |
| 遺伝子ID: | 10095 |
| Uniprot: | O15143 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | ARPC1B, ARC41, p40-ARC, p41-ARC |
| バックグラウンド: | This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. |
| UniProt Protein Function: | ARPC1B: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Belongs to the WD repeat ARPC1 family. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: actin cytoskeleton; Arp2/3 protein complex; cytosol; focal adhesion Molecular Function:actin filament binding; structural constituent of cytoskeleton Biological Process: cell motility; ephrin receptor signaling pathway |
| NCBI Summary: | This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011] |
| UniProt Code: | O15143 |
| NCBI GenInfo Identifier: | 3121763 |
| NCBI Gene ID: | 10095 |
| NCBI Accession: | O15143.3 |
| UniProt Secondary Accession: | O15143,Q9BU00, |
| UniProt Related Accession: | O15143 |
| Molecular Weight: | 40,950 Da |
| NCBI Full Name: | Actin-related protein 2/3 complex subunit 1B |
| NCBI Synonym Full Names: | actin related protein 2/3 complex subunit 1B |
| NCBI Official Symbol: | ARPC1B |
| NCBI Official Synonym Symbols: | ARC41; p40-ARC; p41-ARC |
| NCBI Protein Information: | actin-related protein 2/3 complex subunit 1B |
| UniProt Protein Name: | Actin-related protein 2/3 complex subunit 1B |
| UniProt Synonym Protein Names: | Arp2/3 complex 41 kDa subunit; p41-ARC |
| Protein Family: | Actin-related protein 2/3 complex |
| UniProt Gene Name: | ARPC1B |
| UniProt Entry Name: | ARC1B_HUMAN |