Anti-Arp3 Antibody (CAB4514)
- SKU:
- CAB4514
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ARP3
Description
| 抗体名: | Arp3 Rabbit mAb |
| 抗体コード: | CAB4514 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | ARP3 |
| 申し込み: | WB, IHC, IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human Arp3 |
| 申し込み: | WB, IHC, IF |
| 推奨される希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, Jurkat, U-251MG, Mouse lung, Mouse liver, Mouse spleen, Rat lung, Rat brain, Rat spleen |
| 免疫原: | A synthesized peptide derived from human Arp3 |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 10096 |
| Uniprot: | P61158 |
| セルラーロケーション: | Cell projection, Cytoplasm, cytoskeleton |
| 計算された分子量: | 47kDa |
| 観察された分子量: | 47KDa |
| UniProt Protein Function: | Arp3: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Belongs to the actin family. ARP3 subfamily. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 2q14.1 Cellular Component: Golgi membrane; Arp2/3 protein complex; focal adhesion; hemidesmosome; membrane; lamellipodium; excitatory synapse; podosome; actin filament; intercellular junction; cytosol; actin cytoskeleton Molecular Function:actin filament binding; protein binding; structural constituent of cytoskeleton; ATP binding Biological Process: response to antibiotic; positive regulation of filopodium formation; axon guidance; meiotic chromosome movement towards spindle pole; asymmetric cell division; regulation of myosin II filament assembly or disassembly; establishment and/or maintenance of cell polarity; ephrin receptor signaling pathway; innate immune response; cytokinesis after meiosis; positive regulation of dendrite morphogenesis; cell motility; response to carbohydrate stimulus; spindle localization |
| NCBI Summary: | The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013] |
| UniProt Code: | P61158 |
| NCBI GenInfo Identifier: | 47117647 |
| NCBI Gene ID: | 10096 |
| NCBI Accession: | P61158.3 |
| UniProt Secondary Accession: | P61158,P32391, Q53QM2, |
| UniProt Related Accession: | P61158 |
| Molecular Weight: | 47,371 Da |
| NCBI Full Name: | Actin-related protein 3 |
| NCBI Synonym Full Names: | ARP3 actin-related protein 3 homolog (yeast) |
| NCBI Official Symbol: | ACTR3 |
| NCBI Official Synonym Symbols: | ARP3 |
| NCBI Protein Information: | actin-related protein 3; actin-like protein 3 |
| UniProt Protein Name: | Actin-related protein 3 |
| UniProt Synonym Protein Names: | Actin-like protein 3 |
| UniProt Gene Name: | ACTR3 |
| UniProt Entry Name: | ARP3_HUMAN |