Anti-ARNTL Antibody (CAB17334)
- SKU:
- CAB17334
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-ARNTL Antibody |
抗体コード: | CAB17334 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human ARNTL. |
申し込み: | WB |
推奨希釈: | WB 1:2000 - 1:5000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-87MG, HeLa, 293T, mouse liver, rat testis |
免疫原: | Recombinant protein of human ARNTL. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 406 |
Uniprot: | O003273 |
セルラーロケーション: | |
計算された分子量: | 81kDa |
観察された分子量: | 69kDa |
同義語: | ARNTL, BMAL1, BMAL1c, JAP3, MOP3, PASD3, TIC, bHLHe5, aryl hydrocarbon receptor nuclear translocator like, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, HUTCH-I, ECMR-III |
バックグラウンド: | The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. |
NCBI Summary: | The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
UniProt Code: | O003273 |
NCBI GenInfo Identifier: | |
NCBI Gene ID: | |
NCBI Accession: | |
UniProt Related Accession: | O00327 |
Molecular Weight: | 81kDa |
NCBI Full Name: | |
NCBI Synonym Full Names: | aryl hydrocarbon receptor nuclear translocator like |
NCBI Official Symbol: | ARNTL |
NCBI Official Synonym Symbols: | TIC; JAP3; MOP3; BMAL1; PASD3; BMAL1c; bHLHe5 |
NCBI Protein Information: | aryl hydrocarbon receptor nuclear translocator-like protein 1 |
UniProt Protein Name: | |
Protein Family: | Aryl hydrocarbon receptor nuclear translocator-like protein |
UniProt Gene Name: |
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