Anti-ARL6 Antibody (CAB15198)
- SKU:
- CAB15198
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ARL6 Antibody |
| 抗体コード: | CAB15198 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-186 of human ARL6 (NP_115522.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-186 of human ARL6 (NP_115522.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGLL DRLS VLLG LKKK EVHV LCLG LDNS GKTT IINK LKPS NAQS QNIL PTIG FSIE KFKS SSLS FTVF DMSG QGRY RNLW EHYY KEGQ AIIF VIDS SDRL RMVV AKEE LDTL LNHP DIKH RRIP ILFF ANKM DLRD AVTS VKVS QLLC LENI KDKP WHIC ASDA IKGE GLQE GVDW LQDQ IQTV KT |
| 遺伝子ID: | 84100 |
| Uniprot: | Q9H0F7 |
| セルラーロケーション: | Cell projection, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cilium axoneme, cilium basal body, cilium membrane, cytoskeleton |
| 計算された分子量: | 21kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | ARL6, BBS3, RP55 |
| バックグラウンド: | The protein encoded by this gene belongs to the ARF-like (ADP ribosylation factor-like) sub-family of the ARF family of GTP-binding proteins which are involved in regulation of intracellular traffic. Mutations in this gene are associated with Bardet-Biedl syndrome (BBS). Alternative splicing results in multiple transcript variants of this gene. A vision-specific transcript encoding a different protein has been described (PMID: 20333246). |
| UniProt Protein Function: | ARL6: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization. Defects in ARL6 are a cause of Bardet-Biedl syndrome type 3 (BBS3). Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Defects in ARL6 are the cause of retinitis pigmentosa type 55 (RP55). RP55 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the small GTPase superfamily. Arf family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:G protein; G protein, monomeric, ARF; G protein, monomeric Chromosomal Location of Human Ortholog: 3q11.2 Cellular Component: axoneme; cilium; cytoplasm; membrane; membrane coat; plasma membrane Molecular Function:phospholipid binding; protein binding Biological Process: cilium biogenesis; determination of left/right symmetry; melanosome transport; protein polymerization; protein targeting to membrane; Wnt receptor signaling pathway Disease: Bardet-biedl Syndrome 1; Bardet-biedl Syndrome 3; Retinitis Pigmentosa; Retinitis Pigmentosa 55 |
| NCBI Summary: | The protein encoded by this gene belongs to the ARF-like (ADP ribosylation factor-like) sub-family of the ARF family of GTP-binding proteins which are involved in regulation of intracellular traffic. Mutations in this gene are associated with Bardet-Biedl syndrome (BBS). A vision-specific transcript, encoding long isoform BBS3L, has been described (PMID: 20333246). [provided by RefSeq, Apr 2016] |
| UniProt Code: | Q9H0F7 |
| NCBI GenInfo Identifier: | 14547903 |
| NCBI Gene ID: | 84100 |
| NCBI Accession: | Q9H0F7.1 |
| UniProt Secondary Accession: | Q9H0F7,A8KA93, D3DN31, |
| UniProt Related Accession: | Q9H0F7 |
| Molecular Weight: | 21,960 Da |
| NCBI Full Name: | ADP-ribosylation factor-like protein 6 |
| NCBI Synonym Full Names: | ADP ribosylation factor like GTPase 6 |
| NCBI Official Symbol: | ARL6 |
| NCBI Official Synonym Symbols: | BBS3; RP55 |
| NCBI Protein Information: | ADP-ribosylation factor-like protein 6 |
| UniProt Protein Name: | ADP-ribosylation factor-like protein 6 |
| UniProt Synonym Protein Names: | Bardet-Biedl syndrome 3 protein |
| UniProt Gene Name: | ARL6 |
| UniProt Entry Name: | ARL6_HUMAN |
 | Immunofluorescence analysis of U2OS cells using ARL6 antibody (CAB15198) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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