Anti-ARL2 Antibody (CAB2830)
- SKU:
- CAB2830
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-ARL2 Antibody |
| 抗体コード: | CAB2830 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human ARL2 (NP_001658.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse brain, Mouse kidney, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human ARL2 (NP_001658.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGLL TILK KMKQ KERE LRLL MLGL DNAG KTTI LKKF NGED IDTI SPTL GFNI KTLE HRGF KLNI WDVG GQKS LRSY WRNY FEST DGLI WVVD SADR QRMQ DCQR ELQS LLVE ERLA GATL LIFA NKQD LPGA LSSN AIRE VLEL DSIR SHHW CIQG CSAV TGEN LLPG IDWL LDDI SSRI FTAD |
| 遺伝子ID: | 402 |
| Uniprot: | P36404 |
| セルラーロケーション: | Cytoplasm, Mitochondrion intermembrane space, Nucleus, centrosome, cytoskeleton, microtubule organizing center |
| 計算された分子量: | 18kDa/20kDa |
| 観察された分子量: | 21kDa |
| 同義語: | ARL2, ARFL2 |
| バックグラウンド: | This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. |
| UniProt Protein Function: | ARL2: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Belongs to the small GTPase superfamily. Arf family. |
| UniProt Protein Details: | Protein type:G protein, monomeric, ARF; Mitochondrial; G protein, monomeric Chromosomal Location of Human Ortholog: 11q13 Cellular Component: centrosome; mitochondrial intermembrane space; nucleus; lateral plasma membrane Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding; GTPase inhibitor activity Biological Process: tubulin folding; centrosome organization and biogenesis; metabolic process; small GTPase mediated signal transduction; positive regulation of microtubule polymerization; maintenance of protein localization in nucleus; cell cycle; regulation of microtubule polymerization |
| NCBI Summary: | This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P36404 |
| NCBI GenInfo Identifier: | 116241255 |
| NCBI Gene ID: | 402 |
| NCBI Accession: | P36404.4 |
| UniProt Related Accession: | P36404 |
| Molecular Weight: | |
| NCBI Full Name: | ADP-ribosylation factor-like protein 2 |
| NCBI Synonym Full Names: | ADP ribosylation factor like GTPase 2 |
| NCBI Official Symbol: | ARL2 |
| NCBI Official Synonym Symbols: | ARFL2 |
| NCBI Protein Information: | ADP-ribosylation factor-like protein 2 |
| UniProt Protein Name: | ADP-ribosylation factor-like protein 2 |
| Protein Family: | ADP-ribosylation factor-like protein |
| UniProt Gene Name: | ARL2 |
| UniProt Entry Name: | ARL2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ARL2 antibody (CAB2830) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
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