Anti-ARHGEF11 Antibody (CAB7954)
- SKU:
- CAB7954
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | ARHGEF11 Rabbit Polyclonal Antibody |
| 抗体コード: | CAB7954 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human ARHGEF11 |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse brain |
| 免疫原: | A synthetic peptide of human ARHGEF11 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 9826 |
| Uniprot: | O15085 |
| セルラーロケーション: | Cytoplasm, Membrane |
| 計算された分子量: | 167kDa/172kDa |
| 観察された分子量: | 168kDa |
| 同義語: | ARHGEF11, GTRAP48, PDZ-RHOGEF |
| バックグラウンド: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. |
| UniProt Protein Function: | ARHGEF11: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; GEFs, Rac/Rho; GEFs Chromosomal Location of Human Ortholog: 1q21 Cellular Component: cytoplasm; cytosol; intracellular Molecular Function:G-protein-coupled receptor binding; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; regulation of small GTPase mediated signal transduction; Rho protein signal transduction |
| NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15085 |
| NCBI GenInfo Identifier: | 34395516 |
| NCBI Gene ID: | 9826 |
| NCBI Accession: | O15085.1 |
| UniProt Secondary Accession: | O15085,Q5VY40, Q6PFW2, D3DVD0, |
| UniProt Related Accession: | O15085 |
| Molecular Weight: | 172,244 Da |
| NCBI Full Name: | Rho guanine nucleotide exchange factor 11 |
| NCBI Synonym Full Names: | Rho guanine nucleotide exchange factor 11 |
| NCBI Official Symbol: | ARHGEF11 |
| NCBI Official Synonym Symbols: | GTRAP48; PDZ-RHOGEF |
| NCBI Protein Information: | rho guanine nucleotide exchange factor 11 |
| UniProt Protein Name: | Rho guanine nucleotide exchange factor 11 |
| UniProt Synonym Protein Names: | PDZ-RhoGEF |
| Protein Family: | Rho guanine nucleotide exchange factor |
| UniProt Gene Name: | ARHGEF11 |
| UniProt Entry Name: | ARHGB_HUMAN |
 | Western blot analysis of extracts of mouse brain, using ARHGEF11 antibody (CAB7954) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using ARHGEF11 antibody (CAB7954) (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung using ARHGEF11 antibody (CAB7954) (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon using ARHGEF11 antibody (CAB7954) (40x lens). |
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