Anti-AQP3 Antibody (CAB2838)
- SKU:
- CAB2838
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-AQP3 Antibody |
| 抗体コード: | CAB2838 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 178-292 of human AQP3 (NP_004916.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HT-29, Mouse lung, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 178-292 of human AQP3 (NP_004916.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IVDP YNNP VPRG LEAF TVGL VVLV IGTS MGFN SGYA VNPA RDFG PRLF TALA GWGS AVFT TGQH WWWV PIVS PLLG SIAG VFVY QLMI GCHL EQPP PSNE EENV KLAH VKHK EQI |
| 遺伝子ID: | 360 |
| Uniprot: | Q92482 |
| セルラーロケーション: | Basolateral cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 29kDa/31kDa |
| 観察された分子量: | 31kDa |
| 同義語: | AQP3, AQP-3, GIL |
| バックグラウンド: | This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | AQP3: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. Belongs to the MIP/aquaporin (TC 1.A.8) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter; Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family Chromosomal Location of Human Ortholog: 9p13 Cellular Component: integral to plasma membrane; basolateral plasma membrane; cytoplasm; integral to membrane; plasma membrane; intercellular junction Molecular Function:transporter activity; urea transmembrane transporter activity; water channel activity; glycerol channel activity Biological Process: glycerol transport; positive regulation of immune system process; cellular water homeostasis; response to retinoic acid; water transport; excretion; odontogenesis; response to vitamin D; transport; renal water homeostasis; response to calcium ion; regulation of keratinocyte differentiation; transmembrane transport Disease: Gil Blood Group |
| NCBI Summary: | This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q92482 |
| NCBI GenInfo Identifier: | 2497938 |
| NCBI Gene ID: | 360 |
| NCBI Accession: | Q92482.2 |
| UniProt Secondary Accession: | Q92482,O00108, Q6FGT2, Q6FGW6, A8K843, B2RE16, D3DRL3 |
| UniProt Related Accession: | Q92482 |
| Molecular Weight: | 29,987 Da |
| NCBI Full Name: | Aquaporin-3 |
| NCBI Synonym Full Names: | aquaporin 3 (Gill blood group) |
| NCBI Official Symbol: | AQP3 |
| NCBI Official Synonym Symbols: | GIL; AQP-3 |
| NCBI Protein Information: | aquaporin-3; aquaglyceroporin-3; aquaporin 3 (GIL blood group) |
| UniProt Protein Name: | Aquaporin-3 |
| UniProt Synonym Protein Names: | Aquaglyceroporin-3 |
| Protein Family: | Aquaporin |
| UniProt Gene Name: | AQP3 |
| UniProt Entry Name: | AQP3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AQP3 antibody (CAB2838) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min. |
 | Immunohistochemistry of paraffin-embedded rat kidney using AQP3 Rabbit pAb (CAB2838) at dilution of 1:50 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using AQP3 Rabbit pAb (CAB2838) at dilution of 1:50 (40x lens). |
 | Immunofluorescence analysis of rat kidney using AQP3 antibody (CAB2838) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse kidney using AQP3 antibody (CAB2838) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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