| バックグラウンド: | The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway. |
| NCBI Summary: | The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UKG1 |
| NCBI GenInfo Identifier: | 61213025 |
| NCBI Gene ID: | 26060 |
| NCBI Accession: | Q9UKG1.1 |
| UniProt Secondary Accession: | Q9UKG1,Q9P2B9, |
| UniProt Related Accession: | Q9UKG1 |
| Molecular Weight: | 83 kDa |
| NCBI Full Name: | DCC-interacting protein 13-alpha |
| NCBI Synonym Full Names: | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 |
| NCBI Official Symbol: | APPL1 |
| NCBI Official Synonym Symbols: | APPL; MODY14; DIP13alpha |
| NCBI Protein Information: | DCC-interacting protein 13-alpha |
| UniProt Protein Name: | DCC-interacting protein 13-alpha |
| UniProt Synonym Protein Names: | Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 |
| Protein Family: | DCC-interacting protein |
| UniProt Gene Name: | APPL1 |
