Anti-APOC1 Antibody (CAB5629)
- SKU:
- CAB5629
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
抗体名: | Anti-APOC1 Antibody |
抗体コード: | CAB5629 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | IHC |
反応性: | Human, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-83 of human APOC1 (NP_001636.1). |
申し込み: | IHC |
推奨希釈: | IHC 1:50 - 1:100 |
反応性: | Human, Rat |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-83 of human APOC1 (NP_001636.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MRLF LSLP VLVV VLSI VLEG PAPA QGTP DVSS ALDK LKEF GNTL EDKA RELI SRIK QSEL SAKM REWF SETF QKVK EKLK IDS |
遺伝子ID: | 341 |
Uniprot: | P02654 |
セルラーロケーション: | Secreted |
計算された分子量: | 9kDa |
観察された分子量: |
同義語: | APOC1, Apo-CI, ApoC-I, apo-CIB, apoC-IB |
バックグラウンド: | This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. |
UniProt Protein Function: | APOC1: Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. Belongs to the apolipoprotein C1 family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Lipid-binding; Secreted; Inhibitor; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: chylomicron; endoplasmic reticulum Molecular Function:phospholipase inhibitor activity; lipase inhibitor activity; phosphatidylcholine binding; fatty acid binding Biological Process: positive regulation of catalytic activity; cholesterol metabolic process; triacylglycerol metabolic process; phospholipid efflux; negative regulation of lipid catabolic process; negative regulation of cholesterol transport; negative regulation of lipoprotein lipase activity; cholesterol efflux; lipoprotein metabolic process; negative regulation of receptor-mediated endocytosis; lipid metabolic process; negative regulation of lipid metabolic process; regulation of cholesterol transport; negative regulation of fatty acid biosynthetic process |
NCBI Summary: | The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | P02654 |
NCBI GenInfo Identifier: | 114016 |
NCBI Gene ID: | 341 |
NCBI Accession: | P02654.1 |
UniProt Secondary Accession: | P02654,Q6IB97, B2R526, |
UniProt Related Accession: | P02654 |
Molecular Weight: | 83 |
NCBI Full Name: | Apolipoprotein C-I |
NCBI Synonym Full Names: | apolipoprotein C-I |
NCBI Official Symbol: | APOC1 |
NCBI Official Synonym Symbols: | Apo-CI; ApoC-I |
NCBI Protein Information: | apolipoprotein C-I; apo-CIB; apoC-IB; apolipoprotein C1; apolipoprotein C-I variant I |
UniProt Protein Name: | Apolipoprotein C-I |
UniProt Synonym Protein Names: | Apolipoprotein C1Truncated apolipoprotein C-I |
Protein Family: | Apolipoprotein |
UniProt Gene Name: | APOC1 |
UniProt Entry Name: | APOC1_HUMAN |
Immunohistochemistry of paraffin-embedded human lung using APOC1 antibody (CAB5629) at dilution of 1:100 (40x lens). |