| UniProt Protein Function: | Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. |
| NCBI Summary: | C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8IW19 |
| NCBI GenInfo Identifier: | 27734905 |
| NCBI Gene ID: | 200558 |
| NCBI Accession: | NP_775816.1 |
| UniProt Secondary Accession: | Q8IW19,Q53P47, Q53PB9, Q53QU0, A8K476, |
| UniProt Related Accession: | Q8IW19 |
| Molecular Weight: | |
| NCBI Full Name: | aprataxin and PNK-like factor |
| NCBI Synonym Full Names: | aprataxin and PNKP like factor |
| NCBI Official Symbol: | APLF |
| NCBI Official Synonym Symbols: | APFL; PALF; Xip1; ZCCHH1; C2orf13 |
| NCBI Protein Information: | aprataxin and PNK-like factor |
| UniProt Protein Name: | Aprataxin and PNK-like factor |
| UniProt Synonym Protein Names: | Apurinic-apyrimidinic endonuclease APLF; PNK and APTX-like FHA domain-containing protein; XRCC1-interacting protein 1 |
| Protein Family: | Aprataxin and PNK-like factor |
| UniProt Gene Name: | APLF |
