Anti-APH1B Antibody (CAB17784)
- SKU:
- CAB17784
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-APH1B Antibody |
| 抗体コード: | CAB17784 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human APH1B (NP_112591.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human APH1B (NP_112591.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | GLKS INPG ETAP SMRL LAYV SGLG FGIM SGVF SFVN TLSD SLGP GTVG IHGD SPQF FLYS AFMT LVII LLHV FWGI VFFD GCEK KKWG ILLI VLLT HLLV SAQT FISS YYGI NLAS AFII LVLM GTWA FLAA GGSC RSLK LCLL CQDK NFLL YNQR SR |
| 遺伝子ID: | 83464 |
| Uniprot: | Q8WW43 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | APH-1B, PRO1328, PSFL, TAAV688, APH1B |
| バックグラウンド: | This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011] |
| UniProt Protein Function: | APH1B: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. Belongs to the APH-1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 15q22.2 Cellular Component: integral to membrane; plasma membrane; transport vesicle Molecular Function:peptidase activity; protein binding Biological Process: ephrin receptor signaling pathway; membrane protein intracellular domain proteolysis; Notch receptor processing; Notch signaling pathway; positive regulation of apoptosis; positive regulation of catalytic activity; protein processing |
| NCBI Summary: | This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q8WW43 |
| NCBI GenInfo Identifier: | 61252592 |
| NCBI Gene ID: | 83464 |
| NCBI Accession: | Q8WW43.3 |
| UniProt Secondary Accession: | Q8WW43,Q564N3, Q6UWQ1, Q9H0S0, A8K589, |
| UniProt Related Accession: | Q8WW43 |
| Molecular Weight: | 24,282 Da |
| NCBI Full Name: | Gamma-secretase subunit APH-1B |
| NCBI Synonym Full Names: | aph-1 homolog B, gamma-secretase subunit |
| NCBI Official Symbol: | APH1B |
| NCBI Official Synonym Symbols: | PSFL; APH-1B; PRO1328; TAAV688 |
| NCBI Protein Information: | gamma-secretase subunit APH-1B |
| UniProt Protein Name: | Gamma-secretase subunit APH-1B |
| UniProt Synonym Protein Names: | Aph-1beta; Presenilin-stabilization factor-like |
| Protein Family: | Gamma-secretase |
| UniProt Gene Name: | APH1B |
| UniProt Entry Name: | APH1B_HUMAN |