| バックグラウンド: | A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. |
| NCBI Summary: | A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UJX6 |
| NCBI GenInfo Identifier: | 37537863 |
| NCBI Gene ID: | 29882 |
| NCBI Accession: | Q9UJX6.1 |
| UniProt Related Accession: | Q9UJX6 |
| Molecular Weight: | 93kDa |
| NCBI Full Name: | Anaphase-promoting complex subunit 2 |
| NCBI Synonym Full Names: | anaphase promoting complex subunit 2 |
| NCBI Official Symbol: | ANAPC2 |
| NCBI Official Synonym Symbols: | APC2 |
| NCBI Protein Information: | anaphase-promoting complex subunit 2 |
| UniProt Protein Name: | Anaphase-promoting complex subunit 2 |
| UniProt Synonym Protein Names: | Cyclosome subunit 2 |
| Protein Family: | Anaphase-promoting complex |
| UniProt Gene Name: | ANAPC2 |
| UniProt Entry Name: | ANC2_HUMAN |
