| UniProt Protein Function: | APC11: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. Belongs to the RING-box family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 6.3.2.-; Ligase; Cell cycle regulation; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: anaphase-promoting complex; cytosol; nucleoplasm Molecular Function:ubiquitin-protein ligase activity Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of mitotic metaphase/anaphase transition; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle |
| UniProt Code: | Q9NYG5 |
| NCBI GenInfo Identifier: | 19924286 |
| NCBI Gene ID: | 51529 |
| NCBI Accession: | Q9NYG5.1 |
| UniProt Secondary Accession: | Q9NYG5,Q502X9, Q9BW64, Q9P0R2, A8MTT2, B7ZW64, |
| UniProt Related Accession: | Q9NYG5 |
| Molecular Weight: | 9841 Da |
| NCBI Full Name: | Anaphase-promoting complex subunit 11 |
| NCBI Synonym Full Names: | anaphase promoting complex subunit 11 |
| NCBI Official Symbol: | ANAPC11 |
| NCBI Official Synonym Symbols: | APC11; Apc11p; HSPC214 |
| NCBI Protein Information: | anaphase-promoting complex subunit 11 |
| UniProt Protein Name: | Anaphase-promoting complex subunit 11 |
| UniProt Synonym Protein Names: | Cyclosome subunit 11; Hepatocellular carcinoma-associated RING finger protein |
| UniProt Gene Name: | ANAPC11 |
| UniProt Entry Name: | APC11_HUMAN |
