| UniProt Protein Function: | Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability. |
| NCBI Summary: | The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q86V81 |
| NCBI GenInfo Identifier: | 48429165 |
| NCBI Gene ID: | 10189 |
| NCBI Accession: | Q86V81.3 |
| UniProt Secondary Accession: | Q86V81,O43672, |
| UniProt Related Accession: | Q86V81 |
| Molecular Weight: | 26 kDa |
| NCBI Full Name: | THO complex subunit 4 |
| NCBI Synonym Full Names: | Aly/REF export factor |
| NCBI Official Symbol: | ALYREF |
| NCBI Official Synonym Symbols: | ALY; BEF; REF; THOC4; ALY/REF |
| NCBI Protein Information: | THO complex subunit 4 |
| UniProt Protein Name: | THO complex subunit 4 |
| UniProt Synonym Protein Names: | Ally of AML-1 and LEF-1; Aly/REF export factor; Transcriptional coactivator Aly/REF; bZIP-enhancing factor BEF |
| Protein Family: | Alytesin |
| UniProt Gene Name: | ALYREF |
