Anti-ALKBH8 Antibody (CAB7142)
- SKU:
- CAB7142
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-ALKBH8 Antibody |
抗体コード: | CAB7142 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human ALKBH8 (NP_620130.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:100 |
反応性: | Human, Mouse |
ポジティブサンプル: | A-549, NCI-H460, U-87MG, HeLa, K-562 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human ALKBH8 (NP_620130.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MDSN HQSN YKLS KTEK KFLR KQIK AKHT LLRH EGIE TVSY ATQS LVVA NGGL GNGV SRNQ LLPV LEKC GLVD ALLM PPNK PYSF ARYR TTEE SKRA YVTL NGKE VVDD LGQK ITLY LNFV EKVQ WKEL RPQA LPPG LMVV EEII SSEE EKML LESV DWTE DTDN QNSQ KSLK HRRV KHFG YEFH YENN NVDK DKPL SGGL PDIC ESFL EKWL RKGY IKHK PDQM TINQ YE |
遺伝子ID: | 91801 |
Uniprot: | Q96BT7 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 25kDa/27kDa/75kDa |
観察された分子量: | 75kDa |
同義語: | ALKBH8, ABH8, TRM9, TRMT9 |
バックグラウンド: |
UniProt Protein Function: | ALKBH8: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis. Belongs to the alkB family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA processing; Methyltransferase; EC 2.1.1.229 Chromosomal Location of Human Ortholog: 11q22.3 Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus; cytosol Molecular Function:protein binding; zinc ion binding; tRNA (uracil) methyltransferase activity; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; tRNA binding Biological Process: tRNA wobble uridine modification; response to DNA damage stimulus; tRNA methylation |
UniProt Code: | Q96BT7 |
NCBI GenInfo Identifier: | 189027650 |
NCBI Gene ID: | 91801 |
NCBI Accession: | Q96BT7.2 |
UniProt Secondary Accession: | Q96BT7,Q8N989, B1Q2M0, B4DEF6, |
UniProt Related Accession: | Q96BT7 |
Molecular Weight: | 664 |
NCBI Full Name: | Alkylated DNA repair protein alkB homolog 8 |
NCBI Synonym Full Names: | alkB, alkylation repair homolog 8 (E. coli) |
NCBI Official Symbol: | ALKBH8 |
NCBI Official Synonym Symbols: | ABH8 |
NCBI Protein Information: | alkylated DNA repair protein alkB homolog 8; AlkB homologue 8; probable alpha-ketoglutarate-dependent dioxygenase ABH8; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8 |
UniProt Protein Name: | Alkylated DNA repair protein alkB homolog 8 |
UniProt Synonym Protein Names: | Probable alpha-ketoglutarate-dependent dioxygenase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8 (EC:2.1.1.229) |
Protein Family: | Alkylated DNA repair protein |
UniProt Gene Name: | ALKBH8 |
UniProt Entry Name: | ALKB8_HUMAN |
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