| UniProt Protein Function: | ALDH9A1: Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction. Belongs to the aldehyde dehydrogenase family. |
| UniProt Protein Details: | Protein type:Other Amino Acids Metabolism - beta-alanine; Lipid Metabolism - fatty acid; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Secondary Metabolites Metabolism - limonene and pinene degradation; Carbohydrate Metabolism - ascorbate and aldarate; Oxidoreductase; Amino Acid Metabolism - tryptophan; EC 1.2.1.47; EC 1.2.1.3; Amino Acid Metabolism - arginine and proline; Carbohydrate Metabolism - butanoate; Lipid Metabolism - glycerolipid; Amino Acid Metabolism - histidine; Carbohydrate Metabolism - propanoate; Mitochondrial; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate Chromosomal Location of Human Ortholog: 1q23.1 Cellular Component: cytoplasm; cytosol Molecular Function:3-chloroallyl aldehyde dehydrogenase activity; 4-trimethylammoniobutyraldehyde dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; aminobutyraldehyde dehydrogenase activity Biological Process: aldehyde metabolic process; carnitine biosynthetic process; hormone metabolic process; neurotransmitter biosynthetic process |
| NCBI Summary: | This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49189 |
| NCBI GenInfo Identifier: | 62511242 |
| NCBI Gene ID: | 223 |
| NCBI Accession: | P49189.3 |
| UniProt Secondary Accession: | P49189,Q5VV90, Q6LCL1, Q9NZT7, B2R6X1, B4DXY7, |
| UniProt Related Accession: | P49189 |
| Molecular Weight: | 46,455 Da |
| NCBI Full Name: | 4-trimethylaminobutyraldehyde dehydrogenase |
| NCBI Synonym Full Names: | aldehyde dehydrogenase 9 family member A1 |
| NCBI Official Symbol: | ALDH9A1 |
| NCBI Official Synonym Symbols: | E3; ALDH4; ALDH7; ALDH9; TMABADH |
| NCBI Protein Information: | 4-trimethylaminobutyraldehyde dehydrogenase |
| UniProt Protein Name: | 4-trimethylaminobutyraldehyde dehydrogenase |
| UniProt Synonym Protein Names: | Aldehyde dehydrogenase E3 isozyme; Aldehyde dehydrogenase family 9 member A1 (EC:1.2.1.3); Gamma-aminobutyraldehyde dehydrogenase (EC:1.2.1.19); R-aminobutyraldehyde dehydrogenase |
| Protein Family: | Aldehyde dehydrogenase family |
| UniProt Gene Name: | ALDH9A1 |
| UniProt Entry Name: | AL9A1_HUMAN |
