Anti-ALDH3B1 Antibody (CAB10415)
- SKU:
- CAB10415
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ALDH3B1 Antibody |
| 抗体コード: | CAB10415 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ALDH3B1 (NP_001025181.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, Mouse kidney, Mouse liver, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ALDH3B1 (NP_001025181.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MDPL GDTL RRLR EAFH AGRT RPAE FRAA QLQG LGRF LQEN KQLL HDAL AQDL HKAT QLDS AFIR KEPF GLVL IIAP WNYP |
| 遺伝子ID: | 221 |
| Uniprot: | P43353 |
| セルラーロケーション: | Cell membrane, Lipid-anchor |
| 計算された分子量: | 47kDa/51kDa |
| 観察された分子量: | 52kDa |
| 同義語: | ALDH3B1, ALDH4, ALDH7 |
| バックグラウンド: | This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | ALDH3B1: Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Amino Acid Metabolism - histidine; Amino Acid Metabolism - tyrosine; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - phenylalanine; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.2.1.5; Carbohydrate Metabolism - glycolysis and gluconeogenesis Chromosomal Location of Human Ortholog: 11q13 Cellular Component: cytoplasm; plasma membrane; vesicle Molecular Function:3-chloroallyl aldehyde dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; protein binding Biological Process: alcohol metabolic process; aldehyde catabolic process; lipid metabolic process; sphingolipid biosynthetic process |
| NCBI Summary: | This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
| UniProt Code: | P43353 |
| NCBI GenInfo Identifier: | 1169285 |
| NCBI Gene ID: | 221 |
| NCBI Accession: | P43353.1 |
| UniProt Secondary Accession: | P43353,Q53XL5, Q8N515, Q96CK8, A3FMP9, |
| UniProt Related Accession: | P43353 |
| Molecular Weight: | 47,683 Da |
| NCBI Full Name: | Aldehyde dehydrogenase family 3 member B1 |
| NCBI Synonym Full Names: | aldehyde dehydrogenase 3 family member B1 |
| NCBI Official Symbol: | ALDH3B1 |
| NCBI Official Synonym Symbols: | ALDH4; ALDH7 |
| NCBI Protein Information: | aldehyde dehydrogenase family 3 member B1 |
| UniProt Protein Name: | Aldehyde dehydrogenase family 3 member B1 |
| UniProt Synonym Protein Names: | Aldehyde dehydrogenase 7 |
| Protein Family: | Aldehyde dehydrogenase family |
| UniProt Gene Name: | ALDH3B1 |
| UniProt Entry Name: | AL3B1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ALDH3B1 antibody (CAB10415) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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