Anti-ALDH1A2 Antibody (CAB9123)

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SKU:

CAB9123

Product type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Reactivity:

Mouse

Reactivity:

Rat

Host Species:

Rabbit

Isotype:

IgG

Synonyms:

RALDH(II)

Synonyms:

RALDH2

Synonyms:

RALDH2-T

Description

Description

UniProt Protein Function:	ALDH1A2: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:EC 1.2.1.36; Cofactor and Vitamin Metabolism - retinol; Oxidoreductase Chromosomal Location of Human Ortholog: 15q21.3 Cellular Component: perinuclear region of cytoplasm; cytoplasm; cytosol Molecular Function:aldehyde dehydrogenase (NAD) activity; 3-chloroallyl aldehyde dehydrogenase activity; retinal binding; retinal dehydrogenase activity Biological Process: neural tube development; embryonic forelimb morphogenesis; retinoic acid receptor signaling pathway; heart morphogenesis; retinal metabolic process; neural crest cell development; positive regulation of apoptosis; vitamin A metabolic process; response to estradiol stimulus; response to vitamin A; anterior/posterior pattern formation; neuron differentiation; negative regulation of cell proliferation; morphogenesis of embryonic epithelium; retinol metabolic process; pancreas development; determination of bilateral symmetry; positive regulation of cell proliferation; retinoic acid metabolic process; kidney development; embryonic gut development; proximal/distal pattern formation; hindbrain development; cardiac muscle development; blood vessel development; regulation of endothelial cell proliferation; liver development; embryonic camera-type eye development; pituitary gland development; response to cytokine stimulus; 9-cis-retinoic acid biosynthetic process; midgut development; lung development
NCBI Summary:	This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]
UniProt Code:	O94788
NCBI GenInfo Identifier:	90109797
NCBI Gene ID:	8854
NCBI Accession:	O94788.3
UniProt Secondary Accession:	O94788,Q2PJS6, Q8NHQ4, Q9UBR8, Q9UFY0, B3KY52, B4DZR2 F5H2Y9, H0YM00,
UniProt Related Accession:	O94788
Molecular Weight:	480
NCBI Full Name:	Retinal dehydrogenase 2
NCBI Synonym Full Names:	aldehyde dehydrogenase 1 family, member A2
NCBI Official Symbol:	ALDH1A2
NCBI Official Synonym Symbols:	RALDH2; RALDH2-T; RALDH(II)
NCBI Protein Information:	retinal dehydrogenase 2; RALDH 2; retinaldehyde-specific dehydrogenase type 2
UniProt Protein Name:	Retinal dehydrogenase 2
UniProt Synonym Protein Names:	Aldehyde dehydrogenase family 1 member A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II)
Protein Family:	Retinal dehydrogenase
UniProt Gene Name:	ALDH1A2
UniProt Entry Name:	AL1A2_HUMAN

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