Anti-AKR1C1 Antibody (CAB13004)
- SKU:
- CAB13004
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-AKR1C1 Antibody |
| 抗体コード: | CAB13004 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C1 (NP_001344.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:3000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HeLa, 22Rv1, U-87MG, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C1 (NP_001344.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MDSK YQCV KLND GHFM PVLG FGTY APAE VPKS KALE ATKL AIEA GFRH IDSA HLYN NEEQ VGLA IRSK IADG SVKR EDIF YTSK LWCN SHRP ELVR PALE RSLK NLQL DYVD LYLI HFPV SVKP GEEV IPKD ENGK ILFD TVDL CATW EAVE KCKD AGLA KSIG VSNF NRRQ LEMI LNKP GLKY KPVC NQVE CHPY FNQR KLLD FCKS KDIV LVAY SALG SHRE EPWV DPNS PVLL EDPV LCAL AKKH KRTP ALIA LRYQ LQRG VVVL AKSY NEQR IRQN VQVF EFQL TSEE MKAI DGLN RNVR YLTL DIFA GPPN YPFS DEY |
| 遺伝子ID: | 1645 |
| Uniprot: | Q04828 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 36kDa |
| 観察された分子量: | 38kDa |
| 同義語: | AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB |
| バックグラウンド: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. |
| UniProt Protein Function: | Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. |
| NCBI Summary: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q04828 |
| NCBI GenInfo Identifier: | 416877 |
| NCBI Gene ID: | 1645 |
| NCBI Accession: | Q04828.1 |
| UniProt Secondary Accession: | Q04828,P52896, Q5SR15, Q7M4N2, Q9UCX2, |
| UniProt Related Accession: | Q04828 |
| Molecular Weight: | 36 kDa |
| NCBI Full Name: | Aldo-keto reductase family 1 member C1 |
| NCBI Synonym Full Names: | aldo-keto reductase family 1 member C1 |
| NCBI Official Symbol: | AKR1C1 |
| NCBI Official Synonym Symbols: | C9; DD1; DDH; DDH1; H-37; HBAB; MBAB; HAKRC; DD1/DD2; 2-ALPHA-HSD; 20-ALPHA-HSD |
| NCBI Protein Information: | aldo-keto reductase family 1 member C1 |
| UniProt Protein Name: | Aldo-keto reductase family 1 member C1 |
| UniProt Synonym Protein Names: | 20-alpha-hydroxysteroid dehydrogenase (EC:1.1.1.149 |
| Protein Family: | Aldo-keto reductase family |
| UniProt Gene Name: | AKR1C1 |
 | Western blot analysis of extracts of various cell lines, using AKR1C1 antibody (CAB13004) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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