Anti-AK4 Antibody (CAB19854)[KO Validated]
![Anti-AK4 Antibody (CAB19854)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/18554/18420/anti-ak4-antibody-cab19854ko-validated__36689__86434.1645803989.jpg?c=1 "Anti-AK4 Antibody (CAB19854)[KO Validated]")
- SKU:
- CAB19854
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
![Anti-AK4 Antibody (CAB19854)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/18554/18420/anti-ak4-antibody-cab19854ko-validated__36689__86434.1645803989.jpg?c=1&imbypass=on "Anti-AK4 Antibody (CAB19854)[KO Validated]")
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Description
| 抗体名: | Anti-AK4 Antibody [KO Validated] |
| 抗体コード: | CAB19854 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF IP |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human AK4. |
| 申し込み: | WB IF IP |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HeLa |
| 免疫原: | Recombinant protein of human AK4. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 205 |
| Uniprot: | P27144 |
| セルラーロケーション: | Mitochondrion matrix |
| 計算された分子量: | 25kDa |
| 観察された分子量: | 25KDa |
![Anti-AK4 Antibody [KO Validated] (CAB19854)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/f/609/A19854_1__08778.jpg) | Western blot analysis of extracts from normal (control) and AK4 knockout (KO) HeLa cells, using AK4 antibody (CAB19854) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| 同義語: | AK4, AK 4, AK3, AK3L1, AK3L2 |
| バックグラウンド: | This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. |
| UniProt Protein Function: | AK3L1: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. May also be active with GTP. Belongs to the adenylate kinase family. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; EC 2.7.4.10; EC 2.7.4.6; Mitochondrial; Kinase, other Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: mitochondrion; mitochondrial matrix Molecular Function:GTP binding; nucleoside diphosphate kinase activity; adenylate kinase activity; nucleoside triphosphate adenylate kinase activity; ATP binding Biological Process: response to drug; ATP metabolic process; nucleoside triphosphate biosynthetic process; nucleoside diphosphate phosphorylation; ADP biosynthetic process; brain development; liver development; AMP metabolic process; GTP metabolic process |
| NCBI Summary: | This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P27144 |
| NCBI GenInfo Identifier: | 125157 |
| NCBI Gene ID: | 205 |
| NCBI Accession: | P27144.1 |
| UniProt Related Accession: | P27144 |
| Molecular Weight: | ~ 25kDa |
| NCBI Full Name: | Adenylate kinase 4, mitochondrial |
| NCBI Synonym Full Names: | adenylate kinase 4 |
| NCBI Official Symbol: | AK4 |
| NCBI Official Synonym Symbols: | AK3; AK 4; AK3L1; AK3L2 |
| NCBI Protein Information: | adenylate kinase 4, mitochondrial |
| UniProt Protein Name: | Adenylate kinase 4, mitochondrial |
| UniProt Synonym Protein Names: | Adenylate kinase 3-like; GTP:AMP phosphotransferase AK4 |
| UniProt Gene Name: | AK4 |
| UniProt Entry Name: | KAD4_HUMAN |